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EC number: 205-711-1 | CAS number: 148-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
acute toxicity, oral (OECD 401, RL2), rats: LD50 = 790 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 24 Feb 1987
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Test substance was grounded into a fine powder. - Species:
- rat
- Strain:
- Wistar
- Remarks:
- SPF
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Paderborn, Germany
- Weight at study initiation: 160 - 170 g
- Fasting period before study: 16 h
- Housing: Animals were housed individually during observation period
- Diet: Standard diet (tpf) Altromin, ad libitum
- Water: water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 50 - 60
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- other: Tylose/Tween (1%)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 6 - 12% (depending on test item concentration)
- Amount of vehicle: 1mL/100 g bw
MAXIMUM DOSE VOLUME APPLIED: 1 mL/100 g bw
- Doses:
- 600 (6% in vehicle), 756 (7.5% in vehicle), 953 (9.5% in vehicle) and 1200 (12% in vehicle) mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at least after 1 and 24 h and 7 and 14 days after treatment (not further specified)
- Frequency of weighing: prior to testing and at the end of the observation period
- Necropsy of survivors performed: yes - Statistics:
- Determination of LD50 values according to Litchfield & Wilcoxon and the Gaussian Integral
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 790 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 800 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality was observed in males and females starting at concentrations of 756 and 600 mg/kg bw, respectively (for further details, please refer to Table 1).
- Clinical signs:
- other: 600 mg/kg bw: listlessness, ataxia, lying on side, abdominal pain 756 mg/kg bw: sedation, exophthalmus, staggering, abdominal pain, straggly fur, soft faeces, significantly diminished reflexes 953 mg/kg bw: sedation, staggering, exophthalmus, abdominal pa
- Gross pathology:
- Surviving animals:
600 mg/kg bw: lobular pattern of the liver and gritty or mottled kidneys
756 mg/kg bw: hyperemia of stomach and small intestine, lobular pattern of the liver and gritty or mottled kidneys
953 mg/kg bw: hyperemia of small intestine, slight to pronounced lobular pattern of the liver and mottled or gritty kidneys - Other findings:
- Macroscopic findings summarised for all groups:
stomach: light red to bloody-red (mucous membranes hyperaemised)
small/large intestine: light pink to bloody-red (mucous membranes hyperaemised) - Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Although the available data on acute oral toxicity meet the classification criteria for Acute toxicity Category 4, H302 according to Regulation (EC) No 1272/2008, the registrant follows the suggested classification defined in the RAC opinion for Acute toxicity Category 3, H301 according to Regulation (EC) No 1272/2008.
Reference
Table 1 Results of Mortality
Dose | Mortality 24 h |
Mortality 7 d |
Mortality 14 d |
[mg/kg bw] | |||
N* | N* | N* | |
Males | |||
600 | 0/10 | 0/10 | 0/10 |
756 | 2/10 | 3/10 | 3/10 |
953 | 8/10 | 9/10 | 9/10 |
1200 | 10/10 | 10/10 | 10/10 |
Females | |||
600 | 0/10 | 1/10 | 1/10 |
756 | 3/10 | 3/10 | 3/10 |
953 | 7/10 | 9/10 | 9/10 |
1200 | 9/10 | 10/10 | 10/10 |
N* = number of animals
Table 2 Resulst of average body weight
Dose [mg/kg bw] | Average starting body weight [g] | Average body weight [g] after 14 days |
600 | 165.2±4.54 | 202.1±9.46 |
756 | 165.2±4.21 | 192.6±19.16 |
953 | 163.8±3.74 | 175.0 |
1200 | 164.3±4.32 | - |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 790 mg/kg bw
- Quality of whole database:
- The available information comprises an adequate and reliable (RL1) key study. The information is therefore sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, of Regulation (EC) No 1907/2006.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity
Acute toxicity of quinolin-8-ol (CAS 148-24-3) was tested in Wistar rats according to OECD TG 401 (reference 7.2.1-1). The test substance was administered at concentrations of 600, 756, 953 and 1200 mg/kg bw as suspension in tylose and tween via gavage to groups of 10 males and females. Mortality was observed in males and females starting at concentrations of 756 and 600 mg/kg bw, respectively. In detail, in the highest dose group, all animals died within 48 hours after substance application. At 756 and 953 mg/kg bw, 3/10 and 9/10 males and females died until the end of the observation period, respectively. No mortality was observed in the lower dose groups with except of one female. Clinical signs indicative for systemic toxicity were observed in all dose groups, including ataxia, listlessness, abdominal pain, and sedation and tremor at 953 mg/kg bw. Furthermore, slightly decreased body weight gains correlated to reduced food intake were observed in all dose groups. Necropsy examination revealed a lobular pattern of the liver and mottled kidneys at the lowest dose level. In the higher dose groups, hyperemia of stomach and small intestine were observed. Based on the observed mortalities, a LD50 of 790 and 800 mg/kg bw was derived for females and males, respectively. Thus, as the female animals appeared to be the most sensitive species, an overall LD50 of 790 mg/kg bw is considered for quinolin-8-ol.
In conclusion, quinolin-8-ol is considered to exhibit hazardous properties after single exposure. A LD50 = 790 mg/kg bw is derived.
Justification for classification or non-classification
Although the available data on acute oral toxicity meet the classification criteria for Acute toxicity Category 4, H302 according to Regulation (EC) No 1272/2008, the registrant follows the suggested classification of the RAC opinion for Acute toxicity Category 3, H301 according to Regulation (EC) No 1272/2008. The proposed classification is based on an acute toxicity study following oral exposure in mice in which a LD50 value of 177 mg/kg bw was determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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