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Diss Factsheets
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EC number: 205-160-7 | CAS number: 134-85-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Remarks:
- Experimental data of read across substances
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data for the target chemical is summarized based on the read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- WoE report is based on two short term toxicity to fish studies as-
WoE 2 and WoE 3. - GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: WoE 2- Oryzias latipes, WoE 3- Pimephales promelas
- Details on test organisms:
- Common Name: WoE 2: Japanese rice fish, WoE 3: Fathead minnow
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Reference substance (positive control):
- not required
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1.52 - < 3.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Other details not known
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.72 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Other details not known
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 1.05 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Other details not known
- Details on results:
- 1) Results after 24-hour exposure: - LC50: > 5.50 mg/L, - NOEC: 1.43 mg/L, - LOEC : 2.00 mg/L.
2) Results after 48-hour exposure: - LC50 : 4.60 mg/L (semi-log graph), - NOEC : 1.43 mg/L, - LOEC : 2.00 mg/L.
3) Results after 72-hour exposure: LC50 : 4.60 mg/L (semi-log graph), NOEC : 1.43 mg/L, - LOEC : 2.00 mg/L. - Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, based on mortality effect the 96 hr NOEC, LOEC and LC50 value was determined to be 0.72, 1.05 and > 1.52 to < 3.8 mg/l respectively.
- Executive summary:
Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on fishes. The studies are as mentioned below:
The first study of toxicity to fishes was carried out according to The Notice on the Test Method Concerning New Chemical Substances" guideline. The duration of test was 96 hr performed under static conditions. Oryzias latipes (Japanese rice fish) was taken as test organism. On the basis of mortality effect of test chemical on test organism Oryzias latipes (Japanese rice fish) the 24, 48, 72 hr NOEC and LOEC was determined to be 1.43 and 2.00 mg/L. And the 24,48 and 72 hr LC50 value was determined to be > 5.50 mg/L and 4.60 mg/L (semi-log graph). On the basis of mortality effect of test chemical on test organism Oryzias latipes (Japanese rice fish) the 96 hr NOEC, LOEC and EC50 value was determined to be 0.72 , 1.05 and 3.8 mg/l respectively. As per the value of LC50 the test chemical was considered to be classified in category 'aquatic chronic 2' thus consider as toxic to fishes.
The second study of short term toxicity to fish was carried. The duration of study was 96 hr and was performed under static conditions. Pimephales promelas (fathead minnow) was taken as test organism. On the basis of mortality effect of test chemical on test organism Pimephales promelas (fathead minnow) The 96 hr LC50 value was determined to be 1.52 mg/l with 95% CI of 0.96 to 2.41 mg/L. As per the value of LC50 the test chemical was considered to be classified in category 'aquatic chronic 2' thus consider as toxic to fishes.
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, based on mortality effect the 96 hr NOEC, LOEC and LC50 value was determined to be 0.72, 1.05 and > 1.52 to < 3.8 mg/l respectively. As per the value of LC50 the test chemical was considered to be classified in category 'aquatic chronic 2' thus consider as toxic to fishes.
Reference
Description of key information
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, based on mortality effect the 96 hr NOEC, LOEC and LC50 value was determined to be 0.72, 1.05 and > 1.52 to < 3.8 mg/l respectively.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 1.05 - < 3.8 mg/L
Additional information
Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on fishes. The studies are as mentioned below:
The first study of toxicity to fishes was carried out according to The Notice on the Test Method Concerning New Chemical Substances" guideline. The duration of test was 96 hr performed under static conditions. Oryzias latipes (Japanese rice fish) was taken as test organism. On the basis of mortality effect of test chemical on test organism Oryzias latipes (Japanese rice fish) the 24, 48, 72 hr NOEC and LOEC was determined to be 1.43 and 2.00 mg/L. And the 24,48 and 72 hr LC50 value was determined to be > 5.50 mg/L and 4.60 mg/L (semi-log graph). On the basis of mortality effect of test chemical on test organism Oryzias latipes (Japanese rice fish) the 96 hr NOEC, LOEC and EC50 value was determined to be 0.72 , 1.05 and 3.8 mg/l respectively.
The second study of short term toxicity to fish was carried. The duration of study was 96 hr and was performed under static conditions. Pimephales promelas (fathead minnow) was taken as test organism. On the basis of mortality effect of test chemical on test organism Pimephales promelas (fathead minnow) The 96 hr LC50 value was determined to be 1.52 mg/l with 95% CI of 0.96 to 2.41 mg/L.
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, based on mortality effect the 96 hr NOEC, LOEC and LC50 value was determined to be 0.72, 1.05 and > 1.52 to < 3.8 mg/l respectively. As per the value of LC50 the test chemical was considered to be classified in category 'aquatic chronic 2' thus consider as toxic to fishes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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