Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-597-5 | CAS number: 7212-44-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Remarks:
- Test substance represents a main component (stereoisomer) of the registered substance.
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No quantification of the test substance concentration due to low volatility at room temperature; limited experimental setup allowing no derivation of a LC50.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
- Principles of method if other than guideline:
- An inhalation hazard test was conducted. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (usually 20°C). Several groups of usually 3 rats per sex were sequentially exposed to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted disc in a glass cylinder for different time periods.
No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually was calculated as quotient of the amount of the test substance weight loss during exposure. Group-wise documentation of clinical signs was performed over the 14 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in surviving animals. - GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- (E)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol
- EC Number:
- 255-053-4
- EC Name:
- (E)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol
- Cas Number:
- 40716-66-3
- Molecular formula:
- C15H26O
- IUPAC Name:
- (E)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol
- Details on test material:
- - Name of test material (as cited in study report): trans-Nerolidol
- Physical state: colourless liquid
- Analytical purity: 99 %
- Storage condition of test material: at room temperature
Constituent 1
- Specific details on test material used for the study:
- Test substance represents a main component (stereoisomer) of the registered substance.
Test animals
- Species:
- rat
- Strain:
- other: SPF-Wistar/Chbb:THOM
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, Germany
- Age at study initiation: ca. 8-9 weeks
- Weight at study initiation: males 295 g, females 217 g
- Housing: 3 animals per cage (wire-mesh cages type D III, Becker & Co.) without litter
- Diet: Kliba laboratory diet rat/mouse 24-343-4, 10 mm pellet (Klingentalmuehle AG, Kaiseraugst, Switzerland), ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20-24 °C
- Humidity: 30-70 %
- The animals were housed in fully air-conditioned rooms
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: The animals were exposed to atmosphere saturated with the volatile parts of the test material in the air at 20 °C.
- Details on inhalation exposure:
- Saturation of the atmosphere was generated by conducting an air stream through a substance layer of 5 cm height
The rats were exposed to the test atmosphere for 7 hours
Air flow was 200 l/h in the exposure chamber - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- Vapour saturated air at 20°C (nominal concentration not quantifiable due to low volatility)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of post exposure period until necropsy: 14 days
- Frequency of weighing: Test animals were weighed at test initiation only
- Frequency of observations: The animals were observed daily for mortality and clinical signs of toxicity on working days
- Necropsy of survivors performed: The necropsy of the animals was done on day 14 following exposure
Results and discussion
- Mortality:
- All animals exposed to the test material survived.
- Clinical signs:
- other: Snout wiping was observed during exposure. After exposure no clinical signs were observed.
- Body weight:
- Only initial body weights were recorded.
- Gross pathology:
- Autopsy revealed no findings.
- Other findings:
- Due to the low volatility of the substance at 20 °C, the mean concentration of the test material during 7 h exposure was not determinable by weighing.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.