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EC number: 234-468-4 | CAS number: 12005-50-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-04-21 - 2009-12-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
- Type of study / information:
- This study was performed in order to determine the resorption in the lung of Dodeca¬aluminium calcium nonadecaoxide, Al12O19Ca (Calciumhexaluminate, CA6). The bio-acces¬sible parts were measured.
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Bioaccessibility testing of Cobalt compounds, Woodhall Stopford et al., J. Environ. Monit. 5, 2003, p. 675-680
- Deviations:
- yes
- Remarks:
- Shaking was not performed, no addition of KCl was necessary.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Dodecaaluminium calcium nonadecaoxide
- EC Number:
- 234-468-4
- EC Name:
- Dodecaaluminium calcium nonadecaoxide
- Cas Number:
- 12005-50-4
- Molecular formula:
- Al12O19.Ca
- IUPAC Name:
- dodecaaluminium(3+) calcium nonadecaoxidandiide
Constituent 1
Results and discussion
Any other information on results incl. tables
Calculation of Mobilised Mass
The mobilised masses of the elements were calculated asThe mobilised masses of the two elements were calculated from
wi,mob = (Ci * V )/mE
with
wi,mob = mobilised part in µg/g test item per element
Ci = measured element concentration in µg/L
V = total volume in L of the aqueous phase (0.05 L in all samples)
mE = weight of used test item (nominal: 1.0 g, real weights were used for calc.)
Calculation of Bioaccessibility
Bioaccessibility was calculated as
Ri = (wi,mob * 100%)/ wi,total
with
Ri = bioaccessible part in %
wi,mob = mobilised part in µg/g test item per element
wi,total = total part of the respective element in the test item in µg/g
The mobilised masses of the measured element Al and the bioaccessibilities after 72 hours are presented in the following table:
Bioaccessible Part Al, summary
Parameter |
Mean (72 h) |
Standard Deviation |
Relative Standard Deviation (%) |
Mobilised mass of test item in µg/g |
52.43 |
0.60 |
1.1% |
Bioaccessibility in % |
1.08 * 10-04 |
1.23 * 10-06 |
1.1% |
Because of the presence of Ca in synthetical lung fluid, the bioaccessibility was determined from Al-content only.
Applicant's summary and conclusion
- Conclusions:
- The test item was incubated in synthetical lung fluid (Modified Gambles solution) for a period of three days. Incubation temperature was 37 °C, atmosphere contained 5% CO2.
Samples were taken after 2, 5, 24 and 72 hours incubation time. At each sampling, two flasks were opened and filtrated through 0.45-µm membrane filters. Concentration of the test item was measured using flame AAS after addition of 1% (V/V) conc. HCl. The blanks were analysed at the last sampling point only.
Because of the presence of Ca in synthetical lung fluid, the bioaccessibility was determined from Al-content only.
The mobilised masses of the test item and the bioaccessibility are presented in the following table:
Parameter Mean (72 h) Standard Deviation Relative Standard Deviation (%)
Mobilised mass of test item 52.43 µg/g 0.60 µg/g 1.1%
Bioaccessibility in % 1.08 * 10-04 % 1.23 * 10-06 % 1.1% - Executive summary:
The test item was incubated in synthetical lung fluid (Modified Gambles solution) for a period of three days. Incubation temperature was 37 °C, atmosphere contained 5% CO2.
Samples were taken after 2, 5, 24 and 72 hours incubation time. At each sampling, two flasks were opened and filtrated through 0.45-µm membrane filters. Concentration of the test item was measured using flame AAS after addition of 1% (V/V) conc. HCl. The blanks were analysed at the last sampling point only.
Because of the presence of Ca in synthetical lung fluid, the bioaccessibility was determined from Al-content only.
The mobilised masses of the test item and the bioaccessibility are presented in the following table:
Parameter
Mean (72 h)
Standard Deviation
Relative Standard Deviation (%)
Mobilised mass of test item
52.43 µg/g
0.60 µg/g
1.1%
Bioaccessibility in %
1.08 * 10-04%
1.23 * 10-06%
1.1%
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