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EC number: 203-406-8 | CAS number: 106-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
The
estimated half-life of 1-methylpiperidin-4-ol was estimated to be 74.90
days, indicating that it is very negligibly hydrolysable.
Biodegradation
in water:
The
screening test inherent to the biodegradability of the substance was
calculated using seven different Biowin 1-7 models of the BIOWIN v4.10
software. The results indicate that 4-Piperidinol, 1-methyl- is expected
to be readily biodegradable in water.
Biodegradation
in water and sediment:
Estimated
half life of 4-Piperidinol, 1-methyl- in water was 15 days (360 h) and
in sediment estimated to be 135 days (3240 h).
Biodegradation
in soil:
Biodegradation
half-life of test substance 4-Piperidinol, 1-methyl- in soil was
estimated to be 30 days (720 hrs).
Adsorption/
desorption:
The
Adsorption Coefficient of test substance 1-methylpiperidin-4-ol (CAS No.
106-52-5) was determined as per the HPLC method (OECD Guideline-121).
The Log Koc value was found to be 1.5212 ± 0.009 at 25°C.
Additional information
Hydrolysis:
Predicted
data for test compound4-Piperidinol, 1-methyl-(CAS No. 106-52-5) and its
read across substance for the hydrolysis end point which is summarized
as below:
The Hydrolysis of 1-methylpiperidin-4-ol was predicted using OECD QSAR toolbox version 3.3 (2017). The estimated half-life of 1-methylpiperidin-4-ol was estimated to be 74.90 days.
In supporting study for RA, Hydrolysis of substance Aziridine was studied at neutral pH (7). The half-life of Aziridine was determined to be 154 days.
Base on the above values indicates that the test substance 1-methylpiperidin-4-ol is very negligibly hydrolysable.
Biodegradation in water:
Data for the test compound 4-Piperidinol, 1-methyl-(CAS No. 106-52-5) and the studies for its read across substance were reviewed for the biodegradation end point which is summarized as below:
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound 4 -Piperidinol, 1 -methyl- (CAS no. 106 -52 -5) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that 4-Piperidinol, 1-methyl- is expected to be readily biodegradable in water.
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound 4 -Piperidinol, 1 -methyl-(CAS no. 106 -52 -5).The screening test inherent to the biodegradability of the substance was calculated using the software BIOWIN v4.10. The results indicate that 4-Piperidinol, 1-methyl- is expected to be readily biodegradable.
For supporting study of RA CAS No.105-59-9; Biodegradation study was conducted for evaluating the percentage biodegradability of test substance N-Methyldiethanolamine (SIDS INITIAL ASSESSMENT PROFILE, CoCAM2, Pg. no. 17-19, April 2012). The study was performed according to OECD Guideline 301 A. The percentage degradation of test substance was determined to be 96% after 18 days. Thus, the substance N-Methyldiethanolamine is expected to be readily biodegradable in water.
Further an experimental study for same RA CAS No. 105-59-9 was reported. In this study, the aerobic biodegradability of the chemical N-Methyldiethanolamine (MEDA; CAS No. 105-59-9) was investigated in a standardised continuous flow experiment for a period of 28 days. The parameter TOC was used for determination of degradation during the experiment. MDEA was determined by gas-chromatography fit-ted with a flame ionisation detector) The continuous flow experiment showed a very good biodegradability of the waste water including for high concentrations of MDEA-solution with a TOC-removal of 96%. That implies that the MDEA-solution added to the waste water of the gas sweetening plant was readily biodegradable in nature.
On the basis of above results for target and read across substance, it can be concluded that the test substance 4-Piperidinol, 1-methyl-can be expected to be readily biodegradable in nature.
Biodegradation
in water and sediment:
Estimation
Programs Interface (EPI) Suite (2016) prediction model was run to
predict the half-life in water and sediment for the test compound
4-Piperidinol, 1-methyl- (CAS No. 106 -52 -5). Half life period of
4-Piperidinol, 1-methyl- in water isestimated to be 15 days (360 hrs),
while in sediment it is 135 days (3240 hrs). Based on these half life
values of 4 -Piperidinol, 1 -methyl-, it is concluded that the chemical
is not persistent in water but persistent in sediment.
Biodegradation
in soil:
Based
on EPI prediction Level III Fugacity Model (EPI suite, 2016), the
estimated half-life period of 4-Piperidinol, 1-methyl- (CAS No. 106 -52
-5) in soil was obtained to be 30 days (720 hrs). Based on this
half-life value of 4-Piperidinol, 1-methyl-, it isconcluded that the
chemical is not persistent in the soil environment.
Adsorption/
desorption:
Experimental
and Predicted data of adsorption endpoint for the target chemical
1-methylpiperidin-4-ol (Cas no. 106-52-5) and its read across chemical
were reviewed to summarize as follows:
The adsorption coefficient Koc in soil and in sewage sludge 1-methylpiperidin-4-ol(CAS No.106-52-5) was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals. The reference substances were chosen according to functional similarity with the test substance and calibration graph prepared. The reference substances were 4-chloroaniline 4-methylaniline(p-Tolouidine), N-methylaniline, p-toluamide,, Aniline, 2,5-Dichloroaniline, 4-nitrophenol, 2 - nitrophenol, 2-nitrobenzamide, 3-nitrobenzamide, Nitrobenzene, 4-Nitrobenzamide, 1-naphthylamine, 1-naphtol, Direct Red 81, Benzoic acid methylester, Carbendazim, Benzoic acid phenylester, Xylene, Ethylbenzene, Toluene, Naphthalene, 1,2,3-trichlorobenzene, Pentachlorophenol, Phenol, N,N-dimethylbenzamide, 3,5 - dinitrobenzamide, N-methylbenzamide, Benzamide, phenantrene, Acetanilide having Koc value ranging from 1.25 to 4.09. The Log Koc value was determined to be 1.5212 ± 0.009 at 25°C. This log Koc value indicates that the substance 1-methylpiperidin-4-ol has a low sorption to soil and sediment and therefore has moderate migration potential to ground water.
From predicted model EPI suite 2016 indicate that the soil adsorption coefficient (Koc) value of chemical 1-methylpiperidin-4-ol is estimated to be 4.152 L/kg (log KOC = 0.6182) by means of MCI method at 25 deg.C, indicating that it is has a Negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Whereas from chemspider predicted database the soil adsorption coefficient i.e Koc value of test substance 1-methylpiperidin-4-ol was estimated to be 2.92 L/Kg i.e Log Koc= 0.4653 at pH 7.4. This Koc value indicates that the substance 1-methylpiperidin-4-ol has a Negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
And read across Quinuclidin-3-ol (Cas no. 1619-34-7)experimental study from HSDB authorative database indicate that the adsorption coefficient (Koc) of substance 3-quinuclidinol was found to be 8 L/kg (log Koc 0.903) using a structure estimation method based on molecular connectivity indices.This Koc value suggests that 3-quinuclidinol is expected to have very high mobility in soil.
From same source i.e HSDB database the adsorption coefficient (Koc) of read across substance N-methyldiethanolamine (Cas no. 105-59-9) was found to be 1 L/kg (log koc 0) using a structure estimation method based on molecular connectivity indices. This Koc value suggests that N-methyldiethanolamine is expected to have very high mobility in soil.
Thus based on the above all studies it is concluded that the test substance 1-methylpiperidin-4-ol (Cas no. 106-52-5) has a Negligible to slow sorption to soil and sediment i.e have high to moderate mobility to soil/ sediment.
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