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EC number: 454-190-9 | CAS number: 324763-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: LD50 > 2000 mg/kg bw, (rat, according to EU Method B.1 tris)
Dermal: LD50 > 2000 mg/kg bw (rat, according to EU Method B.3 and OECD guideline 402)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral
In an acute oral toxicity study (Limit Test) conducted by RIOS (2003) according to EU Method B.1 tris, a dose of 2000 mg/kg bw was administered by gavage to 3 Wistar rats per sex. The animals were observed for 15 days for lethality and clinical signs of intoxication. No mortality and no clinical signs of intoxication were observed in males and females. Macroscopic changes were diagnosed during necropsy in all animals. In the lung, lung oedema and small haemorrhage were detected in both sexes.
The LD50 is higher than 2000 mg/kg bw for male and female rats.
Inhalation
There are no data available for acute inhalation toxicity.
Dermal
In an acute toxicity study (Limit Test) conducted by ARC (2005) according to EU Method B.3 and OECD 402 (1987), a single dermal administration of 3-amino-2,2-dimethyl-propionamide was performed by spreading a dose of 2000 mg/kg bw of the undiluted test substance on an area of at least 10% of the estimated body surface of 5 young Wistar rats per sex. The duration of the semi occlusive exposure was 24 hours. At the end of the exposure period the residual test substance was wiped off. The observation period following administration was 14 days. No mortality, no test substance related effects were observed from clinical observations or post-mortem examination. The mean body weight gain shown by the animals over the study period was considered to be similar to that expected of normal untreated animals of the same age and strain. Slight body weight loss was noted in 1/5 females in the first week after dosing. This was assumed to be due to the discomfort, caused by the dressing and was not considered to be toxicologically relevant. Therefore, the LD50 for dermal exposure of 3 -amino-2,2-dimethyl-propionamide is higher than 2000 mg/kg bw for male and female rats.
Justification for classification or non-classification
Based on the oral and dermal LD50 of >2000 mg/kg bw for rats the substance does not need to be classified according to Directive 67/548/EEC and according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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