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EC number: 217-968-7 | CAS number: 2022-85-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-06-07 - 2004-07-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 12 May 1981.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Flucytosine
- EC Number:
- 217-968-7
- EC Name:
- Flucytosine
- Cas Number:
- 2022-85-7
- Molecular formula:
- C4H4FN3O
- IUPAC Name:
- flucytosine
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- please refer to Test material information
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 0 h, 2.4 h, 24 h, 120 h
- Sampling method: Aliquots of the sample solutions were taken from the flasks at various times and the pH of each solution recorded. The concentration of the sample solution was determined by high performance liquid chromatography (HPLC). Samples: Duplicate aliquots (A and B) of sample solution were diluted by a factor of 20 using methanol. Standards: Duplicate standard solutions of test material were prepared in methanol : relevant buffer solution at a nominal concentration of 50 mg/L.
- Sampling intervals/times for pH measurements: 0 h, 2.4 h, 24 h, 120 h - Buffers:
- - pH: 4
- Type and final molarity of buffer:
- Composition of buffer: 50.0 mmol/L Potassium dihydrogen citrate, 9.0 mmol/l Sodium hydroxide
- pH: 7
- Type and final molarity of buffer:
- Composition of buffer: 7.5 mmol/L Disodium hydrogen orthophosphate (anhydrous), 5.0 mmol/L Potassium dihydrogen orthophosphate, 5.0 mmol/L Sodium chloride
- pH: 9
- Type and final molarity of buffer:
- Composition of buffer: 2.5 mmol/L Disodium tetraborate, 5.0 mmol/L Sodium chloride
The buffer solutions were filtered through a 0.2 µm membrane filter to ensure they were sterile before commencement of the test. Also these solutions were subjected to ultrasonication and degassing with nitrogen to minimise dissolved oxygen content. - Details on test conditions:
- TEST SYSTEM
- Sterilisation method: The buffer solutions were filtered through a 0.2 µm membrane filter to ensure they were sterile before commencement of the test.
- Lighting: none
- Measures taken to avoid photolytic effects: The solutions were shielded from light whilst maintained at the test temperature.
- If no traps were used, is the test system closed/open: closed
OTHER TEST CONDITIONS
- Preparation of samples: Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 1.0 g/L in the three buffer solutions.
- Preliminary test: Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5°C for a period of 5 days.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- Calculation
Sample solution concentration
The mean peak area of each standard was corrected to a nominal concentration of 50 mg/L and the mean value taken.
The concentration of the sample solutions (g/L) was calculated using the following equation:
C spl = ( P spl / P std ) * C std * D * ( 1 / 1000)
where:
C spl = sample concentration (g/L)
P spl = mean peak area of sample solution
P std = mean peak area of standard solution, corrected to nominal standard concentration
C std = nominal standard concentration (50 mg/L)
D = sample dilution factor (20)
Results and discussion
- Preliminary study:
- At each pH, less than 10% hydrolysis occured after 5 days at 50°C, equivalent to a half-life greater than 1 year at 25°C.
- Transformation products:
- not specified
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 100
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 2.4 h
- Remarks on result:
- other: Temp: 50.0 ± 0.5ºC
- % Recovery:
- 99.8
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 99.1
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 2.4 h
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 99.8
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 2.4 h
- % Recovery:
- 99.8
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 101
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
Dissipation DT50 of parent compoundopen allclose all
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 400 mg/l. This was satisfactory with a correlation coefficient of 1.000 being obtained.
- Conclusions:
- The estimated half-life at 25°C of the test material at pH 4, pH 7, and pH 9 is > 1 year.
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