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EC number: 207-668-4 | CAS number: 488-10-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 September 2014 - 17 October 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 7346-1 (Determination of the Acute Lethal Toxicity of Substances to a Freshwater Fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)] - Part 1: Static Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Preparation of test solutions started with 100 mg/l, applying a 16 to 18-minute period of magnetic stirring to accelerate the dissolving of the test substance in the test medium. This concentration was prepared in two (range-finding test) or three (final test) batches that were subsequently mixed and used as the highest concentration. The lower test concentrations were prepared by subsequent dilutions of the highest concentration in test medium. The final test solutions were all clear and colourless.
Because the test substance was volatile and sensitive to light, all handlings were performed in closed vessels and under dimmed light. - Vehicle:
- no
- Details on test solutions:
- The batch of the test item was a clear colourless liquid completely soluble in test medium at the concentrations tested.
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Carp
- Strain: Cyprinus carpio
- Length at study initiation: 2.4 ± 0.1 cm
- Weight at study initiation (mean and range, SD): 0.40 ± 0.09 g
- Method of breeding: F1 from a single parent-pair bred in UV-treated water
ACCLIMATION
- Acclimation period: At least 12 days after delivery
- Acclimation conditions: Adjusted ISO medium
- Type of food during acclimation: pelleted fish food
- Feeding frequency during acclimation: Daily
- Health during acclimation (any mortality observed): mortality during the seven days prior to the start of the test was less than 5%
FEEDING DURING TEST
No feeding from 24 hours prior to the test and during the total test period - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 180 mg CaCO3 per litre
- pH:
- 7.7 ± 0.3
- Nominal and measured concentrations:
- Nominal: 4.6, 10, 22, 46 and 100 mg/l.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass
- Type: closed
- Material, size, headspace, fill volume: 6 litres
- Aeration: not aerated during the test
- No. of organisms per vessel: 7 per concentration
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.47 g fish/litre
TEST MEDIUM / WATER PARAMETERS
- Intervals of water quality measurement: Daily
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
mortality and clinical effects
TEST CONCENTRATIONS:
- Range finding study
- Test concentrations: 0.1 to 100 mg/l increasing by a factor of 10. - Reference substance (positive control):
- yes
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 54 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 54 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- weight
- Details on results:
- The actual concentrations were at the level of 94-109% of nominal and remained stable during the test (93-101% of initial). Therefore, the effect parameters were expressed in terms of nominal concentrations.
- Results with reference substance (positive control):
- Study period: 13 January 2014 - 17 January 2014
Concentrations: 0.10, 0.22 and 0.46 mg/l in ISO-medium.
Reference substance: pentachlorophenol
Under the conditions of the present test the reference substance induced no lethal effects in carp at 0.10 mg/l. The 96h-LC50 for carp exposed to the reference substance was 0.24 mg/l. This effect was already reached within 48 hours of exposure. - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study the 96h-LC50 was 54 mg/l based on nominal concentrations (95% confidence interval could not be determined).
Reference
Description of key information
LC50 (96 h) = 54.0 mg/L (nominal, OECD 203, C. carpio)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 54 mg/L
Additional information
There is one study available, in which the short-term toxicity of (Z)-3-methyl-2-(pent-2-en-1-yl)cyclopent-2-enone (CAS 488-10-8) to fish was assessed according to the OECD guideline 203 and GLP.
In a static test, Cyprinus carpio was exposed to the nominal test item concentrations of 4.6, 10, 22, 46, and 100 mg/L for 96 h. The test item concentrations were analytically verified by GC at the start and end of the test.
The measured concentrations were 94 – 109% of nominal at the start of the test and remained stable throughout the test (93 – 101% of initial at test end). Therefore, the effect parameters were expressed in terms of nominal concentrations. After 96 h mortality was observed and an LC50 (96 h) of 54 mg/L was determined (95% confidence interval could not be determined).
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