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EC number: 203-166-4 | CAS number: 104-01-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 23/08/1990 to 24/10/9090
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Toxicity study data from Hoechst Celanese corporation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: AOOECDL-001
- Principles of method if other than guideline:
- Acute oral toxicity study of 4-methoxyphenylacetic acid in rats.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-Methoxyphenyl-Acetic Acid
- IUPAC Name:
- 4-Methoxyphenyl-Acetic Acid
- Reference substance name:
- 4-methoxyphenylacetic acid
- EC Number:
- 203-166-4
- EC Name:
- 4-methoxyphenylacetic acid
- Cas Number:
- 104-01-8
- Molecular formula:
- C9H10O3
- IUPAC Name:
- 2-(4-methoxyphenyl)acetic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): 4-methoxyphenyl acetic acid (MPAA)
- Molecular formula (if other than submission substance): C9-H10-O3
- Molecular weight (if other than submission substance): 166.175
- Smiles notation (if other than submission substance): c1(ccc(OC)cc1)CC(O)=O
- InChl (if other than submission substance): 1S/C9H10O3/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H, 6H2, 1H3, (H,10,11)
- Substance type: Organic
- Physical state: Solid
- Purity-100%
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): (4-methoxyphenyl) acetic acid
- Molecular formula:C9H10O3
- Molecular weight:166.175 g/mole
- Substance type:Organic
- Physical state:White powder or flakes, sliqht odour
- Purity-100%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source: Healthy animals were obtained from SASCO Inc., Omaha, Nebraska.
- Age at study initiation: Males: Approx. 9 week of mle and 12 week of female
- Weight at study initiation: Approximately 190-350 gram at pre-fast. Animal weights fell within 20% of the group mean.
- Fasting period before study: The animals were fasted the night immediately prior to dosing.
-Housing: Animals were housed Individually, separate from other species, in Stainless Steel, wire mesh bottom cages and Each animal was assigned a unique and individual nuaber. This nuaber was peraanently indicated on the aniaal with an ear tag.
Diet (e.g. ad libitum): Fresh certified Agway rodent feed was provided ad libitum, except feed was withheld the night prior to dosing.
- Water (e.g. ad libitum): Fresh potable water was provided ad libitum.
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Within protocol limits of 77.7- 26.1 °C
- Humidity (%):Within protocol limits of 30 – 70%
- Air changes (per hr):No data
- Photoperiod (hrs dark / hrs light): 12/12 hour, light/dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0,2000 and 5000 mg/kg
- Amount of vehicle (if gavage): 1 ml/100 g fasted body weight
- Justification for choice of vehicle: Corn oil
- Lot/batch no. (if required): 19F0038
- Purity: No Data
MAXIMUM DOSE VOLUME APPLIED:5000mg/kg
DOSAGE PREPARATION (if unusual): Test article, homogenized in corn oil at 0,2000 and 5000 mg/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No Data - Doses:
- 0,2000 and 5000 mg/kg
- No. of animals per sex per dose:
- Total: 30
0 mg/kg bw 5 male and 5 female
2000 mg/kg bw 5 male and 5 female
5000 mg/kg bw 5 male and 5 female - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: hourly for the firlt 4 hour immediately after dosing and twice daily (am. and pm ) for the next 13 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: MortalityClinical signs, body weight and gross pathology were examined. - Statistics:
- No details
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - < 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Effect on survival, body weights, Organ weights and gross pathology
- Mortality:
- When treated with 5000 mg/kg, 90% mortality was observed in treated male and female rats as compared to control.
When treated with 2000 mg/kg, 10% mortality was observed in treated male and female rats as compared to control
l. - Clinical signs:
- other: When treated with 5000 mg/kg, oral discharge, nasal discharge, tremors, ataxia abnormal stool, lethargy, Stained coat, alopecia, hunched posture, necrosis, unthriftinees and anal discharge were observed in treated male and female rats as compared to contr
- Gross pathology:
- Liver lesions were observed in all the treated rats at 5000 mg/kg dose group.
Increased incidences of liver lesions relative to control were observed in 2000 mg/kg bw treated male and female rats considered to be treatment related. - Other findings:
- No data available
Any other information on results incl. tables
MORTALITY DATA SUMMARY (DOSE: 5 G/KG)
Day |
0 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
Males Alive |
5 |
3 |
2 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
Males Dead |
0 |
2 |
3 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
Percent Dead |
0 |
0 |
60 |
80 |
80 |
80 |
80 |
80 |
80 |
80 |
80 |
80 |
80 |
80 |
Females Alive |
5 |
3 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Females Dead |
0 |
2 |
4 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
Percent Dead |
0 |
40 |
80 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
MORTALITY DATA SUMMARY (DOSE 2 G/KG)
Day |
0 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
Males Alive |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
Males Dead |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Percent Dead |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Females Alive |
5 |
5 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
Females Dead |
0 |
0 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
Percent Dead |
0 |
0 |
20 |
20 |
20 |
20 |
20 |
20 |
20 |
20 |
20 |
20 |
20 |
20 |
MORTALITY DATA SUMMARY (VEHICLE CONTROL)
Day |
0 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
Males Alive |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
Males Dead |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Percent Dead |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Females Alive |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
Females Dead |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Percent Dead |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- LD50 was considered to be > 2000 mg/kg bw and < 5000 mg/kg bw when rats were treated with 4-methoxyphenylacetic acid orally by gavage in corn oil.
- Executive summary:
In a acute oral toxicity study, Sprague Dawley male and female rats were treated with 4-methoxyphenylacetic acid in the concentration of 0, 2000 and 5000 mg/kg orally by gavage in corn oil and observed for 14 days. 90% mortality was observed at 5000 mg/kg bw and 10% mortality at 2000 mg/kg bw in treated male and female rats as compared to control. Oral discharge, nasal discharge, tremors, ataxia abnormal stool, lethargy, Stained coat, alopecia, hunched posture, necrosis, unthriftinees and anal discharge were observed at 5000 mg/kg in treated male and female rats as compared to control. Decrease in weight was observed in surviving one animal at end of the study at 5000 mg/kg bw, weight gain were observed at 2000 mg/jkg bw and all of the control animals also gained weight through the study period. Liver lesions were observed in all the treated rats at 5000 mg/kg dose group. Increased incidences of liver lesions relative to control were observed in 2000 mg/kg bw treated male and female rats considered to be treatment related. Therefore, LD50 was considered to be > 2000 mg/kg bw and < 5000 mg/kg bw when rats were treated with 4-methoxyphenylacetic acid orally by gavage in corn oil.
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