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Diss Factsheets
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EC number: 228-958-7 | CAS number: 6379-72-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
One experimental study of reliability 4 (based on international guideline and GLP compliance) and two reliable QSAR models were used to assess the aquatic toxicity of the registered substance, (E)-1,2 -Dimethoxy-4 -prop-1 -en-1 -ylbenzene, to fish, aquatic invertebrates and algae.
In the experimental study on aquatic invertebrates Daphnia magna (NOACK, 2000), performed on the registered substance, the 48-EC50 value was determined at 25 mg/L (95% CL: 23 - 27 mg/L), based on nominal concentrations. The test substance was analytically verified only at the beginning of the test, using DOC analysis. No analytical verification of test concentrations was performed at the end of the test. The initial measured concentration at the nominal concentration of 25 mg/L was 16.26 mg/L. As some loss of test substance may be expected during the duration of the test, the mean measured 48h-EC50 value may be expected to be less than 16.26 mg/L. This result is completely in line with the QSAR results on aquatic invertebrates performed on the registered substance which are both very close to the measured value from the daphnid study.
The two QSAR models used were iSafeRat holistic approach v1.4 and ECOSAR v1.11 models. Both QSAR results, performed on the registered substance, were considered reliable as the substance falls within the applicability domain of the models. The results of each model are presented in the table below:
|
iSafeRat holistic approach v1.4 |
ECOSAR v1.11 |
Acute fish |
96h-LC50 = 12 mg/L (95% CL: 11-14 mg/L) |
96h-LC50 = 22.8 mg/L |
Acute daphnid |
48h-EC50 = 13 mg/L (95% CL: 12-14 mg/L) |
48h-LC50 = 14.0 mg/L |
Algae |
72h-ErC50 = 12 mg/L (95% CL: 11-14 mg/L) |
96h-EC50 = 14.8 mg/L |
The E(L)C50 key values, used for chemical safety assessment, were determined as the geometric mean of predicted E(L)C50 values and, when available, measured value (for aquatic invertebrates), corresponding to 16.5 mg/L for fish, 14.4 mg/L for aquatic invertebrates and 13.3 mg/L for algae.
Finally, the registered substance is readily biodegradable and no inhibition effects of the activity of microorganisms was observed in the biodegradation study at 100 mg/L. Therefore, in accordance with column 2 of REACH Annex VIII, the activated sludge respiration inhibition test does not need to be conducted.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.