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EC number: 204-376-9 | CAS number: 120-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
3,4-Dimethoxyphenethylamine (CAS 120-20-7) is acutely harmful to aquatic organisms, according OECD criteria.
Additional information
Ecotoxicity data for 3,4 -dimethoxyphenethylamine (CAS 120-20-7) are available only for fish (acute toxicity) and aquatic microorganisms. Therefore, (Q)SAR models were used to generate the data. In addition, a read-across approach was performed to two structurally similar substances (3,4 -dimethoxyphenylacetonitrile, CAS 93-17-4; 4 -allylveratrole,CAS 93-15-2).
The available data are listed in the table below.
Study |
Results |
Remarks |
|
Short-term toxicity to fish: |
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3,4 -dimethoxyphenethylamine (CAS 120-20-7): |
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BASF AG, 1989, Rep. No.: 10F0747/885014 |
96 -h LC50 > 100 mg/L (pH-adjusted) 96 -h LC50 = 68 mg/L (not pH-adjusted) |
Nominal, DIN 38412, L15, non-GLP |
|
CAS 93-15-2 |
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NITE / J-CHECK, 2003 |
LC50 = 14 mg/L |
Measured, OECD 203, GLP |
|
Environment Canada, 2010 (secondary source) |
LC50 = 6 mg/L (Salmogairdneri) LC50= 8.1 mg/L (Lepomismacrochirus) |
Disregarded due to significant methodological deficiencies: the solvent concentration is exceeding the acceptable level according to OECD 203. Original study performed in 1975 |
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CAS 93-17-4 |
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BASF AG, 1989, Rep. No.: 10F06668/885021 |
LC50 ≥ 100 mg/L |
Nominal, DIN 38412, L15, non-GLP |
|
Conclusion |
3,4 -dimethyoxyphenethylamine (CAS 120 -20 -7) is with high probability acutely not harmful to fish. |
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Short-term toxicity to aquatic invertebrates |
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3,4-Dimethoxyphenethylamine (CAS 120-20-7) |
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ECOSAR v1.11 |
EC50 = 338 mg/L |
In AD |
|
US EPA T.E.S.T. v4.2.1 |
EC50 = 11.5 mg/L |
In AD |
|
VEGA v1.1.3: 1) EPA v1.0.7 2) DEMETRA v1.0.4 |
1) EC50 = 2.5 mg/L 2) EC50 = 9.8 mg/L |
Out of AD |
|
QSAR Toolbox v3.3.5.17: 1) Trend Analysis 1 2) Trend Analysis 2 |
1) EC50 = 36.5 mg/L 2) EC50 = 41.7 mg/L |
In AD |
|
CAS 93-15-2 |
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NITE / J-CHECK, 2003 |
EC50 = 38 mg/L |
Measured, OECD 202, GLP |
|
CAS 93-17-4 |
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BASF AG, Rep. No.:02/0651/50/1 |
EC50 > 100 mg/L |
Nominal test concentrations |
|
Conclusion |
3,4-dimethoxyphenethylamine (CAS 120-20-7) is acutely harmful to aquatic invertebrates. |
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Long-term toxicity to aquatic invertebrates (not an information requirement) |
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CAS 93-15-2 |
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NITE / J-CHECK, 2003 |
NOEC = 1.1 mg/L |
Measured, OECD 211, GLP |
|
Conclusion |
Chronic effects of 3,4-dimethoxyphenethylamine (CAS 120 -20 -7) to aquatic invertebrates are not expected. |
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Toxicity to aquatic algae and cyanobacteria |
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3,4-Dimethoxyphenethylamine (CAS 120-20-7) |
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ECOSAR v1.11 |
EC50 = 338 mg/L ChV= 147 mg/L |
Green algae, In AD |
|
CAS 93-15-2 |
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NITE / J-CHECK, 2003 |
ErC50 = 22 mg/L NOEC = 4.6 mg/L |
Measured, OECD 201, GLP, Rh.subcapitata |
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CAS 93-17-4 |
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BASF AG, 2003, Report No. 02/0651/60/1 |
ErC50 > 100 mg/L ErC10 = 41.8 mg/L NOEC = 25 mg/L |
Nominal, OECD 201, GLP, Rh.subcapitata |
|
Conclusion |
3,4-Dimethoxyphenethylamine (CAS 120-20-7) is acutely harmful to aquatic algae and cyanobacteria. |
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Toxicity to microorganisms |
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3,4-Dimethoxyphenethylamine (CAS 120-20-7) |
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BASF AG, 1988, Rep. No.: 01.0401/88; |
30-min EC20 > 1000 mg/L 30-min EC50 > 1000 mg/L |
Nominal, ISO 8192, respiration inhibition, non-GLP |
|
BASF AG, 1988, Rep. No.: 9/0844/88 |
17-h EC10 = 141 mg/L 17-h EC50 = 200 mg/l |
Nominal, DIN 38412-8, P. putida, growth inhibition, non-GLP |
|
CAS 93-17-4 |
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BASF AG, 2005 Rep. No.: 02/0651/08/1 |
30-min EC20 = 230 mg/L 30-min EC50 = 800 mg/L |
Nominal, OECD 209, respiration inhibition, GLP |
|
Conclusion |
The inhibition of the degradation activity of activated sludge is not anticipated when the 3,4-dimethoxyphenethylamine (CAS 120-20-7) is introduced in appropriately low concentrations |
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Algae turned out to be the most sensitive trophic level (72-h ErC50 = 22 mg/L, 4-Allylveratrole, CAS 93 -15 -2). According to the available data 3,4-dimethoxyphenethylamine (CAS 120-20-7) is considered to be acutely harmful to aquatic organisms
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