Registration Dossier
Registration Dossier
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EC number: 249-050-7 | CAS number: 28479-22-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Method: other: Code of Federal Regulations, Title 16, Section 1500.41; 500 µl of test substance was applied on a 2.5 x 2.5 cm² area at the shaved trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24 and 72 h after start of application.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloro-p-tolyl isocyanate
- EC Number:
- 249-050-7
- EC Name:
- 3-chloro-p-tolyl isocyanate
- Cas Number:
- 28479-22-3
- Molecular formula:
- C8H6ClNO
- IUPAC Name:
- 2-chloro-4-isocyanato-1-methylbenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period:
- up to 8 d
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 24 and 72 h
- Score:
- >= 2.7
- Max. score:
- 8
- Reversibility:
- other: scarring
Any other information on results incl. tables
Within 24 h the skin was white discolorated, fissured and dry
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Executive summary:
500 µl of test substance was applied on a 2.5 x 2.5 cm² area at the shaved trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24 and 72 h after start of application.
Result: substance is corrosive
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