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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: males only, no gross or histopathological evaluation

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
single oral application by gavage of 1, 1.5, 2.0, 2.5, 3.1 ml/kg bw (approx. 1070, 1610, 2140, 2680, 3320 mg/kg bw [d=1.0677g/l]) of the undiluted substance to 10 male Wistar rats per dose; post exposure observation time: 14 d. Calculation of LD50 value according to Fink and Hund (1965) Arzneimittel-forschung 15, 624.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chlorotoluene
EC Number:
203-397-0
EC Name:
4-chlorotoluene
Cas Number:
106-43-4
Molecular formula:
C7H7Cl
IUPAC Name:
4-chlorotoluene
Details on test material:
no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1, 1.5, 2.0, 2.5, 3.1 ml/kg bw (approx. 1070, 1610, 2140, 2680, 3320 mg/kg bw [d=1.0677g/l])
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 2 273 mg/kg bw

Any other information on results incl. tables

signs of toxicity: palmospasms, sedation, at high doses flaccid paralysis   
of the extremities  

[d=1.0677g/l]

Dose[mg/kg bw] // No of rats dead / No of rats with signs of toxicity /  No of rats used // time of death
 
1070 //  0/ 0/10 //  -
1610 //  1/ 1/10 // d 2-3
2140 //  3/10/10 // d 2-3
2680 //  8/10/10 // d 2-3
3320 // 10/10/10 // d 2-3

LD50-value: 2.10 ml/kg bw (ca. 2273 mg/kg bw)

Applicant's summary and conclusion

Interpretation of results:
moderately toxic
Remarks:
Migrated information
Executive summary:

method: single oral application by gavage of 1, 1.5, 2.0, 2.5, 3.1 ml/kg bw (approx. 1070, 1610, 2140, 2680, 3320 mg/kg bw [d=1.0677g/l]) of the undiluted substance to 10 male Wistar rats per dose; post exposure observation time: 14 d.

result: LD50 ca. 2273 mg/kg bw (oral, male rats), signs of toxicity: palmospasms, sedation, at high concentrations flaccid paralysis 

of the extremities