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EC number: 600-289-9 | CAS number: 102213-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5.alpha.-Pregnane-3,11,20-trione, 5,6.alpha.-epoxy-17-hydroxy-, cyclic 3,20-bis(ethylene acetal)
- EC Number:
- 600-289-9
- Cas Number:
- 102213-30-9
- Molecular formula:
- C25H36O7
- IUPAC Name:
- 5.alpha.-Pregnane-3,11,20-trione, 5,6.alpha.-epoxy-17-hydroxy-, cyclic 3,20-bis(ethylene acetal)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- LC-TOF/MS
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna were aged of < 24 hours old.
The culture was originally obtained from PDT department, Smithers Viscient, Harrogate, UK.
Study design
- Test type:
- static
- Water media type:
- other: Elendt M4 medium
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- After 24 and 48 hours, the Daphnia magna in each test vessel were observed for evidence of immobility. The observations differentiated between mobile and immobile daphnids. An individual was considered immobile if, when the contents of the test vessel were briefly agitated, it did not swim during a 15-second period of observation. In addition, Daphnia magna submerged in the body of the test media and those that were held at the surface of the test media were also recorded.
Test conditions
- Hardness:
- Not specified
- Test temperature:
- 21.2-21.3 °C (test start)
19.8-20.0°C (test end) - pH:
- 6.93-6.96 (test start)
7.25-7.40 (test end) - Dissolved oxygen:
- 8.74-9.04 mg/L (test start)
8.87-100 mg/L (test end) - Nominal and measured concentrations:
- Nominal: 0.10, 1.0, 10 and 100%.
Measured: 0.0208, 0.225, 2.26 and 23.3 mg/L. - Details on test conditions:
- Fluorescent lighting
Photoperiod: 16h light/8h dark - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 23.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 23.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 23.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- As the concentrations were outside of the nominal exposure concentration acceptance criteria results are based on geometric mean measured concentrations.
After 48 hours, the concentration at which no significant (=< 10%) dose related immobility occurred was 23.3 mg/L. The NOEC was therefore 23.3 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The validity criteria for control immobility (=< 10%) and dissolved oxygen (>= 3 mg/L) were both satisfied. The test is therefore considered valid.
Based on geometric mean measured concentrations, the 48-h EC50 value was determined to be > 23.3 mg/L. The corresponding NOEC and LOEC were considered to be 23.3 mg/L and > 23.3 mg/L respectively.
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