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EC number: 406-640-0 | CAS number: 136920-07-5 KEROFLUX ES 3241
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- Cited as Directive 84/449/EEC, C.1 ("Acute toxicity for fish")
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The test concentrations were analyzed by determination of DOC in the test water. Test samples were taken at 1 hour and 96 hours after test start.
- Vehicle:
- yes
- Details on test solutions:
- The compound was added to the test water separately for each concentration by mixing with 1 g Tween 80 (100 mg/L). Then, aqua bidest was added in small quantities and the solution was transferred into the test water. A solvent control with the same concentration of solubilizer was run in parallel.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - Common name: Zebra fish
- Source: West Aquarium GMBH, Bad Lauterberg, FRG
- Length at study initiation: 2.9 cm (2.2 - 3.4)
- Weight at study initiation: 0.25 g (0.17 - 0.37)
- Duration of housing and adaptation: about 1.5 months
- Mortality during the last 2 weeks of housing: about 0.8 %
- Medical treatment: None
- Adaptation to the test water: 7 days - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- total hardness: 2.5 mmol/L
- Test temperature:
- 22-23 °C
- pH:
- about 8
- Dissolved oxygen:
- continuous aeration
- Nominal and measured concentrations:
- Based on the results of several range finding studies, the test substance was tested at a range of concentrations: 0, 10.0, 21.5, 46.4, and 100 mg/L.
- Details on test conditions:
- - Photoperiod: 16 hours light and 8 hours darkness
- Volume of water: 10 Liters
- No. of animals per test concentration: 10
- Test vessels: All-glass aquarium (30 cm X 22 cm x 24 cm)
- Test water: Reconstituted freshwater according to DIN 38 412, Part 11
- Aeration: Continuous with oil-free air - Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
- Mortality / Symptoms:
---------------------
No mortality or any symptoms of intoxication were observed at any test concentration.
Concentration control analysis:
-------------------------------
Nominal Conc. DOC [mg/l]
1 h 96 h
-----------------------------------------------------------
10.0 47.5 58.4
21.5 43.9 57.1
46.4 41.6 57.3
100 47.2 55.6
control 1.5 0.6
solvent control 44.1 56.5
-----------------------------------------------------------
The results of the concentration control analysis confirmed the insolubility of the test substance in water even in the presence of a solubilizer.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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