Registration Dossier
Registration Dossier
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EC number: 288-657-1 | CAS number: 85857-16-5
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: no effects observed at 2000 mg/kg bw, the highest dose tested (equivalent to OECD 401, GLP).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
[2-(perfluorohexyl)ethyl]trimethoxysilane has been tested in an acute oral toxicity study conducted according to OECD 423 and in compliance with GLP (BSL Bioservice, 2015a). The undiluted test substance was administered by gavage to two groups, each of 3 female rats. The rats were dosed at 2000 mg/kg bw. There were no deaths and no signs of systemic reaction to treatment during the fourteen day observation period. All animals achieved satisfactory bodyweight gains throughout the study. The LD₅₀ was determined to be >2000 mg/kg bw.
Justification for classification or non-classification
Based on the available acute oral data, [2-(perfluorohexyl)ethyl]trimethoxysilane does not require classification for acute toxicity according to Regulation (EC) No 1272/2008.
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