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Diss Factsheets
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EC number: 220-266-3 | CAS number: 2695-37-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14-28 October 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Test sample, suspended in an appropriate solvent was dosed to test animals by oral gavage. The LD50 was determined according to the Litchfield-Wilcoxon method method. Test procedure is consistent with the requirements of the OECD 401 method.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- mouse
- Strain:
- ICL-ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The mice were kept in the animal room, where temperature was controlled at 22±0.5 oC and its relative humidity was controlled 60±5%. The mice took solid feed CE-2 (CLEA Japan) and drank tap water ab libium
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Since sodium p-styrenesulfonate was solid, the test substance was suspended into olive oil to prepare 40 %(w/v) slurry and used for the test.
- Doses:
- The applied doses were set at 16.00, 13.92, 12.10, 10.52 and 9.14 g/kg
- No. of animals per sex per dose:
- 10 male animals per dose
- Control animals:
- not specified
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 6 400 mg/kg bw
- Based on:
- test mat.
- Remarks:
- A purity correction has been applied to correct for the vehicle content.
- Mortality:
- Tests were conducted at technically maximum dose levels, 16.00, 13.92, 12.10, 10.52 and 9.14 g/kg at 40% in olive oil, but no mortality of the test animal was observed at any dose levels.
- Clinical signs:
- Decrease of spontaneous motion and piloerection were observed after treatment, but the symptoms were disappeared in the next day. Dose groups at 16.00, 13.92 and 12.10 g/kg, light diarrhea were observed.
- Gross pathology:
- At necropsy at the end of test, sodium p-styrenesulfonate treatment group gave no obvious change observations.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Assigning a correction for the content of vehicle, the LD50 of the substance is >6400 mg/kg
- Executive summary:
The acute oral toxicity of the substance has been assessed following dosing of male ICR-SLC mice at dose levels upto 16 g/kg with a dose concentration of 40% in olive oil. Correcting for vehicle content, the maximum dose was 6400 mg/kg of test substance. Dosing was conducted by oral gavage using a test method consistent with the classification OECD 401 style of acute oral toxicity testing, but not in compliance with GLP. No mortality was observed upto the maximum dose. The LD50 >6400mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 6 400 mg/kg bw
- Quality of whole database:
- The data have been accumulated according to a clearly defined test method but not in compliance with GLP.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7-21 April 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted to GLP, but according to an older study guideline.
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- 40 CFR Part 798
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The exposure sites were prepared by clipping the back of each rabbit. The skin of each rabbit remained intact.
Body surface area = 9cm2.
Test site covered by 1 inch2 gauze and covered by elastic adhesive tape - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
- Details on study design:
- Observations: 1,2 and 4 hours on Day 1 then twice daily for the following 13 days
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- Erythema in 6 animals from Day 3, reversible within the observation period in 2 animals. Disquamation in 1 animal on Day 9.
- Body weight:
- No abnormal changes
- Gross pathology:
- No abnormalities observed in 6 animals. Focal or multi-focal red discolouration in 4 animals plus disquamation in 1 of these 4 animals.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 is >2000 mg/kg.
- Executive summary:
The acute dermal toxicity has been assessed by exposure of the substance to 5 male and 5 female New Zealand White rabbits at a dose volume of 2000 mg/kg according to the EPA OTS 798.1100 test method in compliance with GLP. No mortality occurred following single exposure. The dermal LD50 is >2000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Study was conducted to GLP, but according to an older study guideline.
Additional information
Acute Oral Toxicity
The acute oral toxicity of the substance has been assessed following dosing of male ICR-SLC mice at dose levels upto 16 g/kg with a dose concentration of 40% in olive oil. Correcting for vehicle content, the maximum dose was 6400 mg/kg of test substance. Dosing was conducted by oral gavage using a test method consistent with the classification OECD 401 style of acute oral toxicity testing, but not in compliance with GLP. No mortality was observed upto the maximum dose. The LD50 >6400mg/kg.
Acute Dermal Toxicity
The acute dermal toxicity has been assessed by exposure of the substance to 5 male and 5 female New Zealand White rabbits at a dose volume of 2000 mg/kg according to the EPA OTS 798.1100 test method in compliance with GLP. No mortality occurred following single exposure. The dermal LD50 is >2000 mg/kg.
Justification for selection of acute toxicity – oral endpoint
One study is available for this endpoint. The study assesses the acute oral toxicity of the substance in male mice by oral gavage.
Justification for selection of acute toxicity – dermal endpoint
One study is available for this endpoint. The study assesses the acute dermal toxicity of the substance in male and female New Zealand white rabbits by dermal exposure to unabraded skin.
Justification for classification or non-classification
Acute Oral Toxicity
No mortality was observed upto the maximum dose. The LD50 >6400mg/kg.
Acute Dermal Toxicity
No mortality was observed upto the maximum dose. The LD50 >2000mg/kg.
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