Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-131-3 | CAS number: 103-64-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute dermal toxicity of test chemical in rabbits
- Author:
- D. L. J. Opdyke
- Year:
- 1 973
- Bibliographic source:
- Food and Cosmetics Toxicology,1973
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity test was carried out to study the effects of test chemical on rabbits.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- β-bromostyrene
- EC Number:
- 203-131-3
- EC Name:
- β-bromostyrene
- Cas Number:
- 103-64-0
- Molecular formula:
- C8H7Br
- IUPAC Name:
- β-bromostyrene
- Reference substance name:
- β-bromostyrene
- IUPAC Name:
- β-bromostyrene
- Details on test material:
- - Name of test material (as cited in study report):β -Bromostyrene ((2-bromovinyl)benzene)
- Molecular formula :C8H7Br
- Molecular weight :183.0473 g/mole
- Substance type:Organic
- Physical state:Liquid
- Impurities (identity and concentrations):0.4%
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 6000 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 6 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated rabbits at 6000 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 value was considered to be >6000 mg/kg bw,when ratbbits were treated with test chemical by dermal application.
- Executive summary:
In acute dermal toxicity study, rabbits were treated with test chemical in the concentration of 6000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 6000 mg/kg bw.Therefore, LD50 value was considered to be >6000 mg/kg bw,when rabbits were treated with test chemical by dermal application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
