Registration Dossier
Registration Dossier
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EC number: 267-041-6 | CAS number: 67763-18-2
Endpoint summary
Administrative data
Description of key information
Additional information
Diisooctadecyl malate (CAS 67763-18-2) is readily biodegradable according to OECD criteria (81% in 28 d, OECD 301F). Due to the ready biodegradability persistency of the substance in the environment is not expected. Abiotic degradation by hydrolysis is not relevant for the substance as indicated by QSAR calculations resulting in estimated half-lives in water ranging from 174.7 - 330.8 days (at pH 7) and 17.47 - 33.07 days (at pH 8). The substance is furthermore characterised by a low water solubility (6.5-13.5 µg/L at 20 °C), low vapour pressure (VP < 0.0001 Pa at 20°C) and high Koc (>5). Based on these characteristics a distribution to soil and sediment is likely if the substance is released to the environment.
However, an exposure of these environmental compartments is not anticipated, since the substance is expected to be extensively eliminated in conventional sewage treatment plants. In case insoluble chemicals enter a standard Sewage Treatment Plant (STP), they will be largely removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms (Guidance on information requirements and chemical safety assessment, Chapter R.7b; ECHA, 2016). The substance is generally not expected to be present in the water column due to the low water solubility (6.5 - 13.5 µg/L at 20 °C). Furthermore the log Koc range of 8.06 – 21.19 for the main components indicates a potential for adsorption to sewage sludge. Thus, further reduction of the substance concentration in the water column due to adsorption is possible (Guidance on information requirements and chemical safety assessment, Chapter R.7b; ECHA, 2016). Due to the ready biodegradability and the substance characteristics only low concentrations, if any, will be present in the STP effluent .
The volatilization potential of the substance is very low (VP < 0.0001 Pa at 20°C). Nevertheless, if released into the atmosphere, the substance is expected to be rapidly photodegraded based on the estimated half-lives in air, ranging from 3.72 – 7.44 hours (AOPWIN 1.92). An accumulation in air, subsequent transportation and deposition into other environmental compartments is not expected.
Due to the rapid environmental biodegradation and metabolization of the substance via enzymatic hydrolysis a relevant uptake and bioaccumulation in aquatic organisms is not expected. Enzymatic breakdown will initially lead to the free malic acid and isostearyl alcohol. These hydrolysis products will be metabolised and excreted in fish effectively (Tocher, 2003). The low bioaccumulation potential is also indicated by BCF values of 0.89 L/kg calculated for the main components (BCFBAF v3.01, Arnot-Gobas, including biotransformation, upper trophic).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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