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Diss Factsheets
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EC number: 807-715-4 | CAS number: 1354569-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 2016
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The most conservative QSAR estimate on methacrylates is based on acute/chronic ratio due to limited availability of data. As the Log P (7.63) of the test substance is out of applicability domain of the acute toxicity model (maximum 5.0), the result is rated as not reliable.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: QSAR modelling
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other guideline: ECHA Guidance R.6 on QSARs and grouping of substances, May 2008
- Principles of method if other than guideline:
- The QSARs in ECOSAR for both neutral organics (baseline toxicity) and classes with excess toxicity are based on linear mathematical relationships between the predicted log Kow values and the corresponding log of the measured toxicity values (mmol/L) for a suite of training set chemicals within each class of interest.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-bis(2-ethylhexyl) (2Z)-2-methylbut-2-enedioate
- EC Number:
- 807-715-4
- Cas Number:
- 1354569-12-2
- Molecular formula:
- C21 H38 O4
- IUPAC Name:
- 1,4-bis(2-ethylhexyl) (2Z)-2-methylbut-2-enedioate
- Test material form:
- other: in silico
- Details on test material:
- Experimentally determined WS, log P and BP were used for the assessment as "most realistic".
Constituent 1
Test organisms
- Test organisms (species):
- other: freshwater daphnids
- Details on test organisms:
- Species frequently include Desmodesmus subspicatus or Pseudokirchneriella subcapitata.
Test conditions
- Hardness:
- < 150 mg/L CaCO3
- pH:
- 6...8
- Nominal and measured concentrations:
- Measured test concentrations maintained at > 80 % of nominal concentrations.
- Details on test conditions:
- Results adjusted to/measured at 100 % active ingredient.
Results and discussion
Effect concentrations
- Dose descriptor:
- other: Chronic Value SAR (ChV)
- Effect conc.:
- 0.001 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: acute-to-chronic ratio
- Details on results:
- The most conservative QSAR class methacrylates was selected for the dataset.
Any other information on results incl. tables
Please see the ECOSAR modelling printout attached in Section 13 - experimentally determined WS, log P and BP are in a separate attachment.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Conclusions:
- The estimate for chronic toxicity ChV for daphnids was 0.000943 mg/L based on acute/chronic ratio 1/10.
- Executive summary:
The most conservative ECOSAR QSAR estimate for chronic toxicity ChV of methacrylates on daphnids was 0.000943 mg/L based on acute/chronic ratio 1/10. Even if log P of the test substance 7.63 is within the applicability domain of the chronic model (< 8), the estimate is derived from acute fish toxicity results, where the log P is out of the descriptor domain. The result is therefore rated as not
reliable (Klimisch 3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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