Registration Dossier
Registration Dossier
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EC number: 203-564-8 | CAS number: 108-24-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable, reasonably validated
Data source
Reference
- Reference Type:
- publication
- Title:
- A new in vitro method to determine the corrosivity potential of surfactants and surfactant-based formulations.
- Author:
- Gordon, VC et al.
- Year:
- 1 994
- Bibliographic source:
- Comun J Com Esp Deterg 25: 11-27.
Materials and methods
- Principles of method if other than guideline:
- A new in vitro method, CORROSITEX, has been developed to determine the corrosivity potential of chemicals and formulations. This in vitro method assigns corrosive material into packing group I, II and III as described in United Nations guidelines or into R34, R35 and noncorrosive groups based on their ability to produce necrosis in three minutes, one hour, four hours or later, respectively, on the skin of rabbit.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetic anhydride
- EC Number:
- 203-564-8
- EC Name:
- Acetic anhydride
- Cas Number:
- 108-24-7
- Molecular formula:
- C4H6O3
- IUPAC Name:
- acetyl acetate
- Details on test material:
- - Name of test material (as cited in study report): Acetic anhydride
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- other: in vitro
Test system
- Type of coverage:
- other: in vitro system
- Preparation of test site:
- other: in vitro system
- Vehicle:
- unchanged (no vehicle)
- Observation period:
- up to 4 h
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: in vitro parameters
- Value:
- 0
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 50 min. Max. score: 0.0. Remarks: color change occured after 50 minutes. (migrated information)
Any other information on results incl. tables
The color change for acetic anhydride occurred after 50 minutes, rendering the test substance corrosive (packing group II).
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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