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Diss Factsheets
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EC number: 214-353-5 | CAS number: 1122-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Federal Hazardous Substances Act, Section 1500.3. Fed Reg Vol 38, No. 187, p 27014, 1973.
- Deviations:
- yes
- Remarks:
- ; the skin of half the animals was abraded. Few animalsper dose group were tested than in OECD guideline.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N,N-dimethylpyridin-4-amine
- EC Number:
- 214-353-5
- EC Name:
- N,N-dimethylpyridin-4-amine
- Cas Number:
- 1122-58-3
- Molecular formula:
- C7H10N2
- IUPAC Name:
- N,N-dimethylpyridin-4-amine
- Test material form:
- solid: crystalline
- Details on test material:
- The test substance was material prepared in a company lab and recrystallized twice from benzene and three times from benzene/hexane into a fine white crystalline material. It had a constant freezing point of 11.6 degrees C, and a purity of 100% by GLC. The boiling point was 162.5 degrees C, solubility in water of 7.6 g at 25 degrees C, and a flash point of 230 degrees F. This is comparable to current commerical product.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Two male and two female albino rabbits weighing between 2.5 and 3.5 kg each were employed in this study.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Test material was dosed as supplied.
- Duration of exposure:
- 24 hours
- Doses:
- 0.062, 0.125, 0.25, 0.50 g/kg.
- No. of animals per sex per dose:
- 2 male and 2 female per dose group
- Control animals:
- not specified
- Details on study design:
- All animals had their backs clipped free of hair 24 h prior to testing. One half of the clipped animals had their backs abraded prior to dosing. The treated areas of the backs of the animals were covered with large gauze patches and an impervious material was wrapped snugly around the trunk of each animal. The dressings were removed after 24 h and any excess material was removed and the approximate amount of material remaining was noted. The animals were observed for a 14 day period for signs of toxicity and for mortalities. Gross autopsies were performed on all animals which died during the 14-day observation period.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 90 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 62 - <= 125
- Remarks on result:
- other: Reported as 0.09 g/kg.
- Mortality:
- All animals dosed with concentrations over 0.062 g/kg died within the first 5-8 h after dosing.
- Clinical signs:
- other: Animals which died displayed coma.
- Gross pathology:
- No remarkable findings upon necropsy
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information The LD50 is greater than 50 but less than 200 mg/kg bw. Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 in rabbits is 90 mg/kg bw, warranting an Acute Dermal Toxicity classification of Category 2.
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