Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 943-242-0 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (3 h) >= 1000 mg/L (nominal); read-across
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers to activated sludge microorganisms are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS 68855-18-5) was conducted. The source substance is representative to evaluate the toxicity of Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers to activated sludge microorganisms. Both substances are structurally very similar. The target substance is characterized as a diester of neopentylglycol esterified with mainly C18 unsaturated fatty acids. The main constituent of the source substance is neopentyl glycol diesterified with heptanoic acid. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13.
One study is available investigating the toxicity of heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS 68855-18-5) to activated sludge microorganisms. The study was performed according to OECD 209 (GLP) using activated sludge of a predominantly domestic sewage (Roulstone, 2012). The inoculum was exposed to a nominal concentration of 1000 mg/L for 3 h. No effect on the respiration of activated sludge was observed, and the NOEC (3 h) was reported to be ≥ 1000 mg/L.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the target substance Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers will not inhibit the degradation process in sewage treatment plants (STP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
