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EC number: 479-480-2 | CAS number: 17852-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/ corrosion: Key study: Test method according to OECD guideline 404 under GLP conditions, Although there were some effects like yellowdish discoloration in 1/3 animals on day 3 and 4, changes were fully reversible within 6 days.
Eye irritation: Key study: Test method according to OECD guideline 405 under GLP conditions. Brownish or withish areas on the conjunctivae were noted in all the animals, changes were not fully reversible within 22 days.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test method according to OECD 404. GLP study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 500 mg. - Duration of treatment / exposure:
- 4 hours.
- Observation period:
- 72 hours.
- Number of animals:
- 3
- Details on study design:
- SCORING SYSTEM: Scoring system according to OECD guideline 404, EU method B.4.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- other: Max. duration: 5 d.; Max value at end of observation period : 0 (related to all animals)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Max. duration: 0 d.; Max value at end of observation period : 0 (related to all animals)
- Irritant / corrosive response data:
- Reversibility of a y observed effect: Changes fully reversible within 6 days.
- Other effects:
- After 4 hours' exposure to light (three animals), a yellowish discoloration of the treated are of skin was observed in 1/2 of the animals on day 3 and 4.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance showed no potential of skin irritation/corrosion.
- Executive summary:
A skin irritation/ corrosion test was performed according to OECD guideline 404, EU method B.4. and 92/69/EWG. Three New Zealand white rabbits were exposed in semiocclusive conditions to 500 mg of the test substance for 4 hours. A yellowish discoloration of the treated area of skin was observed in 1/3 animals on days 3 and 4. Changes were fully reversible within 6 days.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test method according to OECD 405. GLP study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWWG.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated eye serves as control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 100 mg. - Duration of treatment / exposure:
- Single application.
- Observation period (in vivo):
- 22 days.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: Scoring system according to OECD 405 and EU method B.5.
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 2.3
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 3
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 2.7
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 2.67
- Max. score:
- 3
- Reversibility:
- other: Max duration: h; Max value at the end of observation period: 2 (related to all animals).
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 1.7
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0.9
- Max. score:
- 3
- Reversibility:
- other: Max duration: h; Max value at the end of observation period: 3 (related to all animals).
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0.7
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 1.3
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: overall at 24, 48 and 72h.
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- other: Max duration: h; Max value at the end of observation period: 1 (related to all animals).
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0.7
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 1
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 1
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: overall at 24, 48 and 72 h.
- Score:
- 0.9
- Max. score:
- 1
- Reversibility:
- other: Max duration: h; Max value at the end of observation period: 1 (related to all animals).
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes were not fully reversible within 22 days.
- Other effects:
- Brownish or whitish areas on the conjunctivae were noted in all the animals. Neovascularisation and alopecia around the eye, continuing at the end of the observation period, were observed in 1/3 animals.
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance resulted irritating to the eye of the rabbits. Changes were not fully reversible within 22 days.
- Executive summary:
A study for eye irritation/ corrosion was performed according to OECD 405, EU method B.5 and 92/69/EWG. Three white New Zealand rabbits were instilled 100 mg of the test substance into one eye, the untreated served as control. The following irritation parameters were recorded at 24, 48 and 72 according to OECD 404 scoring system: Conjunctivae score (redness), chemosis score, cornea score and iris score. Adverse effects were seen for all irritation parameters. Changes were not fully reversible within 22 days. The substance can be classified as ocular irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Eye irritation: Key study: A study for eye irritation/ corrosion was performed according to OECD 405, EU method B.5 and 92/69/EWG. Three white New Zealand rabbits were instilled 100 mg of the test substance into one eye, the untreated served as control. The following irritation parameters were recorded at 24, 48 and 72 according to OECD 404 scoring system: Conjunctivae score (redness), chemosis score, cornea score and iris score. Adverse effects were seen for all irritation parameters. Changes were not fully reversible within 22 days.
Skin irritation/ corrosion: Key study:
A skin irritation/ corrosion test was performed according to OECD guideline 404, EU method B.4. and 92/69/EWG. Three New Zealand white rabbits were exposed in semiocclusive conditions to 500 mg of the test substance for 4 hours. A yellowish discoloration of the treated area of skin was observed in 1/3 animals on days 3 and 4. Changes were fully reversible within 6 days.
Justification for selection of skin irritation / corrosion endpoint:
Only one study available.
Justification for selection of eye irritation endpoint:
Only one study available.
Effects on eye irritation: corrosive
Justification for classification or non-classification
The minor effects and the reversibility seen in the skin irritation study are not sufficient to classify the substance for skin irritation/ corrosion.
Given that changes are not fully reversible within 22 days of observation at the eye irritation study, the test substance classify for irreversible effects on the eye. (Category 1)
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