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EC number: 202-993-8 | CAS number: 101-97-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study the LD50 was determined to be 3300 mg/kg bw.
In an acute dermal toxicity study the LD50 was determined to be >5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Sex:
- not specified
- Doses:
- 1480, 2200, 3330 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 (total number of animals per dose, sex not specified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Dose 2220 mg/kg bw = 2 animals
Dose 3330 mg/kg bw= 4 animals
Dose 5000 mg/kg bw= 10 animals - Clinical signs:
- 5000 mg/kg bw = Lethargy
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity study the LD50 was determined to be 3300 mg/kg bw.
- Executive summary:
In a study of Moreno, 1973, the acute oral toxicity of the test item was determined. The study was conducted with 10 rats per group. The test item was administered in doses of 1480, 2220, 3330 and 5000 mg/kg bw. The animals were observed for mortality and/or systemic effects for 14 days. Mortality was observed in doses from 2200 mg/kg bw onwards. The LD50 was determined to be 3300 mg/kg bw. Lethargy was observed in animals of the highest dose group.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 300 mg/kg bw
- Quality of whole database:
- Only basic data given, no GLP study, acceptable, well documented publication, similar to guideline
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Sex:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals (total numer of animals, sex not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1/10
- Clinical signs:
- In 5/10 animals anorexia on days 1, 2
1/10 animals extreme weakness prior to death - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal toxicity study the LD50 was determined to be >5000 mg/kg bw.
- Executive summary:
The acute dermal toxicity of the test item was determined. The study was conducted with 10 rabbits. They received a dermal application of 5000 mg/kg bw. The animals were observed for mortality and/or systemic effects for 14 days. One of 10 animals died during the study. The calculated LD50 was determined to be >5000 mg/kg bw. Toxic effects were found in 5/10 animals on days 1 and 2. They showed signs of anorexia. An extreme weakness was found in 1 animal prior to death.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Basic data given, acceptable, well documented publication, no GLP study, similar to guideline
Additional information
Acute oral toxicity
Key study
Acute toxicity study on rats and rabbits (Moreno, 1973)
The acute oral toxicity of the test item was determined. The study was conducted with 10 rats per group. The test item was administered in doses of 1480, 2220, 3330 and 5000 mg/kg bw. The animals were observed for mortality and/or systemic effects for 14 days. Mortality was observed in doses from 2200 mg/kg bw onwards. The LD50 was determined to be 3300 mg/kg bw. Lethargy was observed in animals of the highest dose group.
Acute dermal toxicity
Key study
Acute toxicity study on rats and rabbits (Moreno 1973)
The acute dermal toxicity of the test item was determined. The study was conducted with 10 rabbits. They received a dermal application of 5000 mg/kg bw. The animals were observed for mortality and/or systemic effects for 14 days. One of 10 animals died during the study. The calculated LD50 was determined to be >5000 mg/kg bw. Toxic effects were found in 5/10 animals on days 1 and 2. They showed signs of anorexia. An extreme weakness was found in 1 animal prior to death.
Justification for selection of
acute toxicity – oral endpoint
Only basic data given, no GLP study, acceptable, well documented
publication, similar to guideline
Justification for selection of acute toxicity – dermal endpoint
Basic data given, acceptable, well documented publication, no GLP
study, similar to guideline
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) 1272/2008 (CLP). As a result the substance is not considered to be classified for acute oral toxicity, for acute inhalation toxicity and for acute dermal toxicity under Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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