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EC number: 219-101-8 | CAS number: 2359-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
HEOX-CN (CAS 2359 -11 -7) was administered by oral gavage to five rats of each sex per group, at 2000 mg/kg body weight. Animals were subjected to daily observations, and body weight determinations weekly and at death. Macroscopic examination was performed on the day of death or at the end of the experimental period (day 15). Clinical signs of toxicity were observed in all animals on the day of treatment. The severity and number of symptoms were increased in the females. From day 6 onwards, signs of toxicity were again observed in three females, resulting in the death of one animal on day 9. The symptoms had completely disappeared by day 14 in the other two animals. Enlarged kidneys were found in one of the latter females at macroscopic post mortem examination. Body weight loss or reduced body weight gain were observed in these three females over the first week. The sensitivity of the females to HEOX-CN after oral administration appeared to be higher than in the males.
The oral L050 value of HEOX-CN in rats was established as exceeding 2000 mg/kg body weight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rat, Wistar strain Crl:(WI) BR (outbred, SPFQuality).
Source : Charles River, Germany.
Age: Approx. 6 weeks.
WBody weight: ithin ± 20% of the sex mean.
5 males and 5 females
Identification: Earmark
Air-conditioned room with approximately 15 air changes per hour and the environment controlled with optimal conditions considered as being a temperature of 21°C and a relative humidity of 50%. Fluctuations from these optimal conditions were noted, but were considered not to have affected study integrity. Lighting was 12 hours artificial fluorescent light and 12 hours dark per day.
Accommodation
Group housing of 5 animals per sex per cage in labelled polycarbonate cages containing purified sawdust as bedding material (Woody SPF, supplied by B.M. I., Helmond, The Netherlands). Certificates of analysis were examined and then retained in the NDTDX a rchives.
Acclimatisation period was at least 5 days before start of treatment under laboratory conditions.
Diet
Free access to standard pelleted laboratory animal diet (from Carfil Quality BVBA, Dud-Turnhout, Belgium). Certificates of analysis are examined and then retained in the NOT OX archives.
Water
Free access to tap-water. Certificates of analysis (performed quarterly) are examined and then retained in the NOTOX archives
IN-LIFE DATES: From: To: - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Food was withheld overnight prior to dosing until approximately 3-4 hours after administration of the test substance.
Oral gavage, Once, on day 1: 2000 mg/kg (1.905 ml/kg) body weight.
Dose volume calculated as follows: dose level (g/kg): density (g/mol). - Doses:
- 2000 mg/kg (1.905 ml/kg) body weight.
- Control animals:
- no
- Details on study design:
- Mortality/Viability: Twice daily. The time of death was recorded as precisely as possible.
Body weights: Days 1 (pre-administration), 8 and 15. and at death (if found dead after day 1).
Clinical signs: At periodic intervals on the day of dosing (day 1) and once daily thereafter, until day 15. The time of onset,
degree and duration were recorded.
Necropsy: All animals surviving to the end of the observation period (day 15) were sacrificed by oxygen/carbon dioxide asphyxiation.
All animals assigned to the study were sUbjected to necropsy and descriptions of all macroscopic abnormalities recorded.
- Statistics:
- No statistical analysis was performed.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality: One female was found dead on day 9.
- Clinical signs:
- other: Lethargy and uncoordinated movements were observed in all males on day 1. Lethargy, uncoordinated movements, hunched posture, ventro-lateral recumbency and/or piloerection were observed in the females on day 1. From day 6 onwards, signs of toxicity were a
- Gross pathology:
- Macroscopic Findings:
Partial cannibalism prohibited complete post mortem examination of the female that died during the study. No abnormalities were found in the organs present. Enlarged kidneys were found in one surviving female at macroscopic post mortem examination. - Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 value of HEOX-CN in rats was established as exceeding 2000 mg/kg body weight. The sensitivity of the females to HEOX-CN after oral administration appeared to be higher than in the males.
- Executive summary:
The study was carried out in accordance with OECD Guideline No. 401, "Acute Oral Toxicity' and EEC Directive 92/69/EEC, Part B.1, 'Acute Toxicity-Oral'. This study should provide part of a rational basis for risk assessment in man. The oral route was selected as it is a possible route of human exposure during manufacture, handling or use of HEOX-CN.
HEOX-CN (CAS 2359 -11 -7) was administered by oral gavage to five rats of each sex per group, at 2000 mg/kg body weight. Animals were subjected to daily observations. Body weights were determined weekly and at death. Macroscopic examination was performed on the day of death or at the end of the experimental period (day 15). Clinical signs of toxicity were observed in all animals on the day of treatment. The severity and number of symptoms were increased in the females. From day 6 onwards, signs of toxicity were again observed in three females, resulting in the death of one animal on day 9. The symptoms had completely disappeared by day 14 in the other two animals. Enlarged kidneys were found in one of the latter females at macroscopic post mortem examination. Body weight loss or reduced body weight gain were observed in these three females over the first week. The sensitivity of the females to HEOX-CN after oral administration appeared to be higher than in the males.
The oral LD50 value of HEOX-CN in rats was established as exceeding 2000 mg/kg body weight. According to the Guidance to Regulation (EC) No. 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, November 2012, the test substance is not classified.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- satisfactory
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for selection of acute toxicity – oral endpoint
A well conducted experimental GLP study per OECD 401 test guideline.
Justification for classification or non-classification
According to the Guidance to Regulation (EC) No. 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, November 2012, the test substance is not classified.
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