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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 700-283-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1 - 30 Apr 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- OECD 429
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- sukls28108/2009
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Reaction products of acetic acid and acetylferrocene and butan-1-ol and 2-methylpropan-1-ol and propan-1-ol and propan-2-ol
- EC Number:
- 700-283-7
- Molecular formula:
- Exact molecular formula is not known as it is a reaction mass. Empiric formula: C5H5FeC5H4COCmHn
- IUPAC Name:
- Reaction products of acetic acid and acetylferrocene and butan-1-ol and 2-methylpropan-1-ol and propan-1-ol and propan-2-ol
- Details on test material:
- According to INQ-C-0000036278-61-01, INQ-C-0000036386-62-01, and INQ_RESULT_INQ-C-0000036417-65-01 from ECHA, identification of a substance has been changed to UVCB substance. Name of the substance on the study results is the old name (reaction mass of butan-1-ol and propan-2-ol, ReduxCo), however these reports should be regarded valid as all studies were performed on the substance that is being registered - ReduxCo.
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- other: DAE 433 - mixture of 40% dimethylacetamide, 30% acetone and 30% ethanol
- Concentration:
- Positive control DNCB: 0,5 (w/v)
ReduxCo: 30%, 3%, 0.3% (v/v) in DAE 433 - No. of animals per dose:
- Total 36:
- 3 females - pilot experiment
- 18 females (6 animals in 3 groups)
- 6 females - positive control group
- 6 females - negative control group
- 3 females - reserve group - Positive control substance(s):
- other: DNCB (dinitrochlorobenzene)
Results and discussion
- Positive control results:
- The positive control substance DNCB elicited a reaction pattern with statistically significant increase in ear weight and LN hyperplasia, which was in congruence with the expected mode of action of a contact allergen.
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: Ear weight index: 1.05 LN weight: 1.2 LN cell count: 1.3
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: not known
Any other information on results incl. tables
Comparison of values between treated groups and control grpups revealed that the test substance, ReduxCo, did not cause statistically significant increase in LN cell count and LN weight. Also index of LN cell count and LN weigh were not exceeded in any dose level,.
The animals exposed to test substance at all concentrations showed no skin reactions or negative clinical symptoms of intoxication throughout the experiment.
According to criteria given, the results were considered as negative.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Under the given test conditions, the test substance, ReduxCo, elicited negative response in LLNA test.
- Executive summary:
Based on LLNA results the test substance, ReduxCo, does not have to be classified as the substance, which may cause sensitisation by skin contact.
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