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EC number: 268-358-2 | CAS number: 68081-84-5 This substance is identified by SDA Substance Name: C10-C16 alkyl glycidyl ether and SDA Reporting Number: 15-076-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 of male rats was > 27.4 and < 31.6 mL/kg bw. Therefore the mean oral LD50 of male rats was 30.1 mL/kg bw or 26800 mg/kg bw (density = 0.89g/cm3).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1974
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Cited from ECHA disseminated dossier Query date: 2015-07-22 For justification of read across please refer to IUCLID section 13.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Four groups each of 10 male rats and one group of 20 male rats were treated with the undiluted substance. The application volume was 17.8 mL/kg, 23.7 mL/kg, 27.4 mL/kg and 31.6 mL/kg, respectively. One control group with 10 male rats was treated with demineralized water at 31.6 mL/kg.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Control group: 31.6 mL/ kg demineralized water
Test group 1: 17.8 mL/kg
Test group 2: 23.7 mL/kg
Test group 3: 27.4 mL/kg
Test group 4: 31.6 mL/kg - No. of animals per sex per dose:
- Control group: 10 males
Test group 1: 10 males
Test group 2: 10 males
Test group 3: 10 males
Test group 4: 20 males - Control animals:
- yes
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 30.1 mL/kg bw
- Remarks on result:
- other: equivalent to 26800 mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 26 800 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Four groups each of 10 male rats and one group of 20 male rats were treated with the undiluted substance. The single-application volume was 17.8 mL/kg, 23.7 mL/kg, 27.4 mL/kg and 31.6 mL/kg, respectively. One control group with 10 male rats was treated with demineralized water at 31.6 mL/kg.
Mortality and clinical signs were observed during 14 days after treatment.
No deaths occurred in the control group and test groups treated with 17.8 mL/kg, 23.7 mL/kg and 27.4 mL/kg.
16 out of 20 rats died in the highest treated group (31.6 mL/kg) during the course of the study.
Systemic toxicity was observed in all test item treated groups. All clinical signs disapeared in the lowest treated group (17.8 mL/kg) after day 4 where where as the animals treated with 23.7 mL/kg, 27.4 mL/kg and the surviving animals treated with 31.6 mL/kg still showed clinical signs at the end of the observation period.
Loss of body weight was noted in the 31.6 mL/kg treated group during the first week of observation but the surviving animals did not recover completly at the end of the observation period compared with the control animals. Body weight increased in the other treated groups was comparable to the control group.
For the 31.6 mL/kg treated animals, red discoloration of the stomach with hemmorhage was noted at the unscheduled necropsy in 12 out of 16 animals. Blood in the stomach was observed in 5 animals. Red discoloration of the small intestine with hemmorhage was observed in 10 animals and blood in the small intestine was seen in 12 animals.
The oral LD50 of male rats was > 27.4 and < 31.6 mL/kg bw. Therefore the mean oral LD50 of male rats was 30.1 mL/kg bw or 26800 mg/kg bw (density = 0.89g/cm3).
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for acute toxicity under Directive 67/548/EEC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for acute toxicity under Regulation (EC) No. 1272/2008.
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