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EC number: 229-912-9 | CAS number: 6834-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to basic scientific principles, study report provides only summary of data, with no/very few tables with data from individual animals. There were discrepancies between the study report and the abstract (Ito, 1986).
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Safety of anticorrosives in building water-pipe methal inhibitors sodium polyphosphate and sodium metasilicate.
- Author:
- Ito, R. et al.
- Year:
- 1 986
- Bibliographic source:
- Toxicol. Lett. 31 (Suppl. P1-28), 44
- Reference Type:
- publication
- Title:
- Safety of the metal scavengers sodium metasilicate and sodium polyphosphate.
- Author:
- Saiwai, K. et al.
- Year:
- 1 980
- Bibliographic source:
- Internal Report Toho University
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
- Principles of method if other than guideline:
- Standard acute oral toxicity
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium metasilicate
- EC Number:
- 229-912-9
- EC Name:
- Disodium metasilicate
- Cas Number:
- 6834-92-0
- Molecular formula:
- H2O3Si.2Na Soluble Silicates Category
- IUPAC Name:
- disodium oxosilanediolate
- Details on test material:
- SOURCE: Not reported
PURITY: Not reported
IMPURITY/ADDITIVE/ETC.: Not reported
ANY OTHER INFORMATION: Sodium metasilicate was administered as a 10% solution.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: T23-48:ddy
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Source: Sankyo Laboratory Service
- Age: 4 weeks
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- - Volume administered or concentration: 0.05-0.19 ml/10g for males, 0.05-0.14 ml/10g for females
- Doses:
- 500-1920.8 mg/kg (males), 500-1372 mg/kg (females)
- Control animals:
- not specified
- Details on study design:
- - Post dose observation period: seven days
EXAMINATIONS: mortality, clinical symptoms, histopathology
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 770 - 820 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 661.5 - 896.3 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 666.7 - 1 008.6 mg/kg bw
- Remarks on result:
- other: 66.7-1087.6 mg/kg is reported in Ito, 1986
Any other information on results incl. tables
MORTALITY:
- Time of death: 4 hrs - 5 days
CLINICAL SIGNS:
2 minutes after administration males and
females became lethargic and had a hunched posture. Tear
flow increased with dose level. Surviving animals recovered
within 2-4 days. The animals that died were lethargic, did
not react to external stimuli, had hanging eyelids,
paralysis of hind legs, clonicity and tonic cramps, followed
by cyanosis and respiratory paralysis.
NECROPSY FINDINGS:
the following symptoms increased with
increasing dose: localised bleeding in the mucous membranes
of the "glandular stomach", duodenum, mucous membranes of
the central part of the "small gut", capillary dilation,
rarefaction of the stomach lining, clear liver lobules,
faded colour of the liver rim, redness of the gall. Animals
dosed 1372 mg/kg and above had bleeding and inflammation
extending from the "glandular stomach"to the central part of
the "small gut". In surviving animals the liver lobules
looked slightly clearer and the spleen showed slight
rubefaction, compared to control group animals.
POTENTIAL TARGET ORGANS: stomach, liver, gut.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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