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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 457-670-6 | CAS number: 157859-20-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
No data are available with terrestrial organisms.
Testing for toxicity to terrestrial organisms is not considered necessary because:
- the registered substance hydrolyses extremely rapidly to produce tris(1-methylethyl)silanol and acrylic acid.
- a PNECsoil for has been calculated for tris(1-methylethyl)silanol from the corresponding PNECaqua(freshwater) on the basis of the equilibrium partitioning method.
- a PNECsoil for acrylic acid has previously been calculated in an EU Risk assessment Report based on the results of a respiration inhibition test conducted with soil microflora.
The risk characterisation ratios (RCRs) derived on the basis of these PNECsoil values are all <1 (see Section 10 of the CSR).
PNECsoil has been calculated from the aquatic data using the Equilibrium Partitioning Method. The risk characterisation ratios (RCR) based on the PNECsoil are <1.
In accordance with Column 2 of REACH Annex IX, there is no need to further investigate the effects of this substance in a terrestrial toxicity to invertebrates/higher plants study because, as indicated in guidance R.7.11.6 (ECHA 2016), the quantitative chemical safety assessment (conducted according to Annex I of REACH) indicates that the Risk Characterisation Ratio (RCR) is below 1 and therefore the risk is already adequately controlled and further testing is not justifiable.
The substance rapidly hydrolyses and the silanol hydrolysis product is not readily biodegradable but has low potential for bioaccumulation and low potential for adsorption. Toxicity was observed in aquatic tests. Distribution modelling for STP indicates that water is the main compartment to which the silanol is expected to partition in a sewage treatment plant, as well as the main compartment to which it will partition in the wider environment. Therefore, the occurrence of more severe toxic effects in the terrestrial compartment that were not expressed in the aquatic studies (conducted at concentrations up to 100 mg/l) would be considered unlikely.
Overall it is concluded that the risk characterisation conclusion is sufficiently conservative and therefore further in vivo testing is not considered necessary.
Details on how the PNEC and the risk characterisation ratio have been derived can be found in IUCLID Section 6.0 and Chapters 9 and 10 of the Chemical Safety Report, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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