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EC number: 241-022-2 | CAS number: 16949-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Magnesium hexafluorosilicate hexahydrate
- Cas Number:
- 18972-56-0
- Molecular formula:
- MgSiF6·6H2O
- IUPAC Name:
- Magnesium hexafluorosilicate hexahydrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 177g (male) 157g (female)
- Fasting period before study: 15h-20h
- Diet (e.g. ad libitum): Herilan MRH-Haltung
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50%, 10%, 6.81%, 4.64%, 3.16%, 2.15%
- Amount of vehicle (if gavage) (ml/kg): 10
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg - Doses:
- 6 dose groups:
Dosis: 5000 mg/kg, 1000 mg/kg, 681 mg/kg, 464 mg/kg, 316 mg/kg, 215 mg/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 2-4 D, 7 D and 13 D
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs (dyspnoe, rattle, apathy, anomalous situation, stagger, atony, pain reflex, cornea reflex, anesthesia, tremble, twitch, clonic convulsions, shaggy fur, diarrhea, cyanosis, exsiccosis, chromodacryorrhea, general worse), body weight - Statistics:
- Model of the dose-effect relationship: F(P) = A + B·LN(D)
Explanation: D=Dosis; P=Relative frequency of the dead animals after exposure to D; F=Inverse function of the cumulative normal distribution stander; LN=Natural logarithm; A,B= model parameters
Result: A=-26.26 scattering A=7.89; B=4.63 scattering B=1.39
Results and discussion
- Preliminary study:
- NA
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 291 mg/kg bw
- Based on:
- dissolved
- 95% CL:
- > 246 - < 342
- Mortality:
- Dosis mg/kg Mortality after 14D %
215 10
316 60
464 100
6 81 100
1000 100
5000 100 - Clinical signs:
- other: symptoms (dosis with symptoms mg/kg) dyspnoe (5000, 1000, 681, 464, 316) rattle (1000) apathy (5000, 1000, 681, 464, 316) anomalous situation (5000, 1000, 681, 464) stagger (1000, 681, 464, 316) atony (5000, 681) pain reflex (681) cornea reflex (681) anes
- Gross pathology:
- Animals that died: heart: right acute dilatation, acute hyperaemia; stomach: glandular stomach diffusely reddened, partly large-scale bloody ulcers, intestinal: atonic, reddened mucous membrane inflammation
- Other findings:
- NA
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Acute Tox. 3 Criteria used for interpretation of results: EU
- Conclusions:
- The results showed a LD50 after 14 days of 291 mg/kg.
- Executive summary:
In an in vivo test, the acute oral toxicity effects in rats of Magnesium Hexafluorosilicate Hexahydrated
were studied.The product was administered by gavage once to the animals. The investigations included the mortality in 14 days, poisoning symptoms and section of acute died and died after the test period with carbon dioxide. The animals were 30 male and 30 female Sprague Dawley Wiga Rats. The substance was administrated as a solution with distillated water via oral with a fasting period of 15-20 hours for application. The rats were divided in six test groups (5 male/ 5 female) with different dosis (5000 mg/kg, 1000 mg/kg, 681 mg/kg, 464 mg/kg, 316 mg/kg, 215 mg/kg). The results showed a LD50 after 14 days of 291 mg/kg with a slope factor of 1,24.
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