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EC number: 203-471-2 | CAS number: 107-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50/LC50 values derived form the key-studies were: LD50 (oral, rat) 56.4 mg/kg bw, LD50 (dermal, rabbit) 88 mg/kg bw, LC50 (2 h inhalation, rat) 2000 mg/m³. Based on these results, propargyl alcohol is considered to be toxic following acute oral, dermal or inhalation exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 56.4 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 2 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 88 mg/kg bw
Additional information
The BASF study from 1963, where a LD50 of 56.4 mg/kg bw was derived, has been identified as key-study. This study represents the most reliable study as a reliable source of test material was used and the test was done according to a well described BASF method which was in compliance with the principles of OECD Guideline 401. Agitation, hyperventilation and prone position of animals were noticed as clinical sings after application. The LD50 value is supported by additional data, where LD50 values of 50 – 145 mg/kg bw were reported in the rat (Stasenkova and Kochetkova, 1966; Vernot et al., 1977, BASF Toxicology Department, 1967; Archer, 1986).
The LD50 values in the mouse were ca. 50 mg/kg body weight (Stasenkova and Kochetkova, 1966; Burton, 1964)
In an acute dermal toxicity study using female rabbits the LD50 was 88 mg/kg bw (Vernot, 1977). This is the most reliable study as it is well documented and was done in compliance with the principles of OECD Guideline 402.
In the acute inhalation toxicity study by Stasenkova and Kochetkova (1966), groups of 10 rats were exposed via the inhalation route to Propargyl alcohol at nominal concentration of 3, 5, 10, 15 and 20 mg substance/l for 2 hours. Animals exposed to high concentrations showed quickly after beginning of exposure mucous membrane irritation, apathy, dyspnoea and lateral position (lying on the side). The inhalation LC50 in the rat was 2000 mg/m³ for an exposure period of 2 hours. This is the most reliable study as it is well documented and was done in compliance with the principles of OECD Guideline 403.
This LC50 value is supported by additional data (Vernot et al., 1977), where LC50 values of 2750 mg/m³ (male rats) and 2420 mg/m³ (female rats) were derived from studies with 1 h exposure.
Justification for classification or non-classification
Based on the results for acute oral (LD50 rat 56 mg/kg bw), acute dermal (LD50 rabbit 88 mg/kg bw) and inhalation toxicity (LC50 rat (2h) 2 mg/L) Propargyl alcohol is classified for acute toxicity as follows:
acute toxicity: cat. 3, H301, toxic if swallowed; cat. 2, H310, fatal in contact with skin; cat. 2, H330, fatal if inhaled (according to Regulation 1272/2008/EC)
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