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Diss Factsheets
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EC number: 201-607-5 | CAS number: 85-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- GLP compliance:
- no
- Specific details on test material used for the study:
- phthalic anhydride, purity >= 98 % (FA Merck)
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- solvent: DMSO < 100 µl/l
test concentration: 5 - 7, a solvent and blank control; range between the concentrations
was 3.2 - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 60 d
- Test temperature:
- 10 +/- 1 °C
- Duration:
- 60 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: total embryotoxicity
- Duration:
- 60 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: any effects: mortality, lengh, weight, embryotoxicity
- Details on results:
- Geometric series of 7 test concentrations using a factor of 3.2 was used. With a factor of 3.2 the next lowest concentration is 10 mg/l which
corresponds to the no effect concentration (NOEC) of 10 mg/l. - Executive summary:
A chronic toxicity test of phthalic anhydride to fish was performed with Oncorhynchus mykiss (Salmo gairdneri) according to the OECD Guideline Draft "Early Life Stage". After 60 days an effective LOEC of 32 mg/l was determined. Geometric series of 7 test concentrations using a factor of 3.2 were used. With a factor of 3.2 the next lowest concentration is 10 mg/l which corresponds to the no effect concentration (NOEC). Not only mortality but also other endpoints like total embryotoxicity were tested (Van Leeuwen, 1990).
Reference
RS-Freetext:
EC50 (Total Embryotoxicity): 44.1 mg/l
LC50 : 44.2 mg/l
LOEC (mortality): 32 mg/l
LOEC (total embryotoxicity): 32 mg/l
LOEC (length): 32 mg/l
LOEC (weight): 32 mg/l
LOEC: The lowest concentration which differed significantly from the control.
Geometric series of 7 test concentrations using a factor of 3.2 was used. With a factor of 3.2 the next lowest concentration is 10 mg/l which corresponds to the no effect concentration (NOEC) of 10 mg/l.
RS-Freetext:
The LC50 and 95 % confidence limits were determined according to Kooyman (1981)*. Concentrations affecting survival with more than 50 % were excluded from the statistical analyses. The Bartlett test was used to test the data for homogeneity of variances. Differences were considered significant at alpha < 0.01.
* Kooyman SALM (1981). Parametric analyses of mortality rates in bioassays. Water Res. 15, 107-119.
Description of key information
Concerning long-term toxicity of phthalic anhydride to fish, an early life stage toxicity test according to the Draft Guideline OECD 210 was carried out in buffered medium using Salmo gairdneri (new name: Oncorhynchus mykiss) as test species. A NOEC of 10 mg/l was derived from the test results (Van Leeuwen, 1990).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 10 mg/L
Additional information
A chronic toxicity test of phthalic anhydride to fish was performed with Oncorhynchus mykiss (Salmo gairdneri) according to the OECD Guideline Draft "Early Life Stage"210 in buffered medium under semistatic conditions. Fertilised eggs and the following early-life stages of fish were exposed to geometric series of 7 test concentrations for 60 days. An effective LOEC of 32 mg/l was determined. With a factor of 3.2 the next lowest concentration is 10 mg/l which corresponds to the no effect concentration (NOEC). Not only mortality but also other endpoints like total embryotoxicity were tested (Van Leeuwen, 1990).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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