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Diss Factsheets
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EC number: 619-057-3 | CAS number: 94667-33-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The read across to Bardap 26 is supported by a set of bridging studies for DDAC and ADBAC demonstrating the similarity in physico-chemical, toxicological, ecotoxicological and movement and fate properties of these quaternary substances. The quaternary ammonium compound (Bardap 26) for which read across is requested, and the two substances used for read across (DDAC and ADBAC) belong to the family of cationic surfactants. Within this family they form a well-defined subgroup of substances with similar chemical structure; (1) one or two hydrophobic, non-branched alkyl chains with a main chain length distribution of C10-16, (2) one to three methyl group substituents and (3) a hydrophilic group carrying a positively charged quaternary nitrogen atom.
- Reason / purpose for cross-reference:
- read-across source
- Type:
- BCF
- Value:
- 38 dimensionless
- Basis:
- edible fraction
- Time of plateau:
- 10 d
- Calculation basis:
- steady state
- Remarks on result:
- other: predicted BCF = 52
- Remarks:
- Conc.in environment / dose:93 ± 32 µg/l
- Type:
- BCF
- Value:
- 140 dimensionless
- Basis:
- non-edible fraction
- Time of plateau:
- 10 d
- Calculation basis:
- steady state
- Remarks on result:
- other: Predicted BCF = 160
- Remarks:
- Conc.in environment / dose:93 ± 32 µg/l
- Key result
- Type:
- BCF
- Value:
- 81 dimensionless
- Basis:
- other: whole body
- Remarks on result:
- other: Predicted BCF = 95
- Elimination:
- yes
- Parameter:
- other: Elimination after 14 Days 57% (edible tissue)
- Elimination:
- yes
- Parameter:
- other: Elimination after 18 Days 38% (edible tissue)
- Elimination:
- yes
- Parameter:
- other: Elimination after 14 Days 71% (non-edible tissue)
- Elimination:
- yes
- Parameter:
- other: Elimination after 18 Days 66% (non-edible tissue)
- Key result
- Elimination:
- yes
- Parameter:
- other: Elimination after 14 Days 67% (whole body)
- Elimination:
- yes
- Parameter:
- other: Elimination after 18 Days 56% (whole body)
Reference
Description of key information
One key study is available which was conducted in accordance with US EPA Guideline 165-4 using Bluegill fish as the test species, exposed to the test material at concentrations of 0 and 59.0 µg/l for 28 days exposure period. Under the conditions of this study, for edible tissue, the BCF was 38 (predicted 52) and elimination after 14 and 18 Days was 57% and 38%, respectively. For non-edible tissue, the BCF was 140 (predicted 160) and elimination after 14 and 18 Days was 71% and 66%, respectively. For whole-body, the BCF was 81 (predicted 95) and elimination after 14 and 18 Days was 67% and 56%, respectively.
Key value for chemical safety assessment
- BCF (aquatic species):
- 81 dimensionless
Additional information
In a study conducted in accordance with U.S.EPA (1989), Bluegill fish (Lepomis macrochirus) was exposed to the test material, Bardac 22 with radiolabelled Didecyldimethylammonium Chloride at concentrations of 0, 59.0 µg/l (actual concentration - 93 ± 32 µg/l). 220 bluegill were tested at each concentration. The test organisms were exposed to the test material in aquaria for 28 days, with an 18 day depuration period. Fish were collected on days 4, 10, 17, 24 and 28 of the exposure and on days 3, 7, 14 and 18 of depuration. Tissues from control fish were sampled on days 0 and 28 of exposure and day 18 of depuration. On day 28 of exposure, an additional five fish were sampled and divided into three tissue portions; edible (fillets), non-edible (head, fins and viscera) and skin. Edible tissues from each of three sets of approximately 10 fish sampled on day 28 were subjected to hexane/methanol tissue extraction, combusted and then counted to quantify that portion of the 14C-residue not extractable with either solvent. Five treated fish died during the exposure test and no fish died during depuration. Under the conditions of this study, for edible tissue, the BCF was 38 (predicted 52) and elimination after 14 and 18 Days was 57% and 38%, respectively. For non-edible tissue, the BCF was 140 (predicted 160) and elimination after 14 and 18 Days was 71% and 66%, respectively. For whole-body, the BCF was 81 (predicted 95) and elimination after 14 and 18 Days was 67% and 56%, respectively. In conclusion, Skin tissue showed 14C-residues 2 to 6 times higher than edible tissue portions. The test substance may bind significantly to skin and scales of exposed fish. Of the accumulated 14C-residue in the edible tissue of bluegill exposed 28 days to the test substance, 65.5% was extractable with a polar solvent (methanol), 8.1% was extractable with a nonpolar solvent (hexane) and 25.9% was not extractable with either solvent.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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