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EC number: 263-423-1 | CAS number: 62125-22-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to guideline, but with restrictions (limited information on test substance, observation period only 72 hours).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- Adopted 24 April 2002
- Deviations:
- yes
- Remarks:
- limited information on test substance, observation period only 72 h
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Federal Register, 1973, Vol. 38, No. 187, Section 1500:42
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2-bis[[(1-oxoisooctadecyl)oxy]methyl]-1,3-propanediyl bis(isooctadecanoate)
- EC Number:
- 263-423-1
- EC Name:
- 2,2-bis[[(1-oxoisooctadecyl)oxy]methyl]-1,3-propanediyl bis(isooctadecanoate)
- Cas Number:
- 62125-22-8
- Molecular formula:
- not available UVCB
- IUPAC Name:
- 3-[(3-methylnonadecanoyl)oxy]-2,2-bis({[(3-methylnonadecanoyl)oxy]methyl})propyl 3-methylnonadecanoate
- Details on test material:
- - Name of test material (as cited in study report): only trade name given
- Analytical purity: no data
- Physical state: liquid
- Colour: yellow (clear)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Housing: in grid bottomed galvanised metal cages
- Diet: 90 - 95 g / day, Product Ref. 16934, Spillers Agriculture Limited
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Air changes: air conditioned room
- Photoperiod (hrs dark / hrs light): 14 / 10
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL
- Concentration: 100 % - Duration of treatment / exposure:
- 72 h
- Observation period (in vivo):
- 72 h
Reading time points: 24, 48 and 72 h - Number of animals or in vitro replicates:
- 6 females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE: no
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0.78
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks:
- observation only for 72 h, reversibility was not studied
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0.22
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- 24 h after exposure, chemosis was observed in 4 of 6 animals, which disappeared the next day. All 6 animals showed redness of the conjunctivae, which dissapeared in 3 animals the next day. At 72 h observation, redness was still observed in 2 animals. Since the observation was stopped after 72 h, there is no information on the reversibility of these effects in the remaining 2 animals.
Adverse effects on the cornea and the iris were not observed in any of the animals.
Any other information on results incl. tables
Table 1: Evaluation of the eye reaction
Rabbit No. / sex |
Scoring [h] |
Cornea |
Iris |
Conjunctiva |
|
Redness |
Chemosis |
||||
1 / f |
24 |
0 |
0 |
2 |
0 |
48 |
0 |
0 |
0 |
0 |
|
72 |
0 |
0 |
0 |
0 |
|
Mean (24, 48, 72 h) |
0 |
0 |
0.67 |
0 |
|
2 / f |
24 |
0 |
0 |
2 |
1 |
48 |
0 |
0 |
0 |
0 |
|
72 |
0 |
0 |
0 |
0 |
|
Mean (24, 48, 72 h) |
0 |
0 |
0.33 |
0.33 |
|
3 / f |
24 |
0 |
0 |
2 |
0 |
48 |
0 |
0 |
1 |
0 |
|
72 |
0 |
0 |
1 |
0 |
|
Mean (24, 48, 72 h) |
0 |
0 |
1.33 |
0 |
|
4 / f |
24 |
0 |
0 |
1 |
1 |
48 |
0 |
0 |
1 |
0 |
|
72 |
0 |
0 |
0 |
0 |
|
Mean (24, 48, 72 h) |
0 |
0 |
0.67 |
0.33 |
|
5 / f |
24 |
0 |
0 |
1 |
1 |
48 |
0 |
0 |
1 |
0 |
|
72 |
0 |
0 |
1 |
0 |
|
Mean (24, 48, 72 h) |
0 |
0 |
1.0 |
0.33 |
|
6 / f |
24 |
0 |
0 |
1 |
1 |
48 |
0 |
0 |
0 |
0 |
|
72 |
0 |
0 |
0 |
0 |
|
Mean (24, 48, 72 h) |
0 |
0 |
0.33 |
0.33 |
|
Group mean (24, 48, 72h) |
0 |
0 |
0.78 |
0.22 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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