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EC number: 231-635-3 | CAS number: 7664-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published, public domain data.
Data source
Reference
- Reference Type:
- publication
- Title:
- Data on the toxicologic characteristics of the single, brief effect of ammonia on animals.
- Author:
- Prokop'eva, A.S., Yushkov, G.G. and Ubasheev, I.O.
- Year:
- 1 973
- Bibliographic source:
- GIG TR PROF ZABOL; 17 (6). 1973 56-57
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Assessment of skin irritation in the rat in vivo following exposure to the gaseous substance
- GLP compliance:
- no
- Remarks:
- : older, published study
Test material
- Reference substance name:
- Ammonia, anhydrous
- EC Number:
- 231-635-3
- EC Name:
- Ammonia, anhydrous
- Cas Number:
- 7664-41-7
- Molecular formula:
- H3N
- IUPAC Name:
- ammonia
- Details on test material:
- No further details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- The test animal is a white rat. No other details are given.
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- The concentration was varied. Visible signs of pathology appeared only at an ammonia concentration of 20-30 mg/L and higher.
- Duration of treatment / exposure:
- The length of time the skin of the animal was exposed to ammonia was varied. The time length ranged from 5-60 mins.
- Observation period:
- The observation period was the duration of the exposure therefore between 5-60 mins.
- Number of animals:
- The number of animals is not stated.
- Details on study design:
- Ammonia was applied to the skin of rats for 5-60 mins. The effects of application were noted.
Results and discussion
In vivo
Results
- Remarks on result:
- other: The visible signs of skin pathology appeared only at an ammonia concentration of 20-30 mg/L and higher, mainly in the form of a burn around the anus and in the region of the external genitalia.
- Irritant / corrosive response data:
- The visible signs of skin pathology appeared only at an ammonia concentration of 20-30 mg/L and higher, mainly in the form of a burn around the anus and in the region of the external genitalia.
- Other effects:
- No further effects
Any other information on results incl. tables
The measure of skin corrosion was determined by using the LC50, which is tabulated below. The visible signs of skin pathology appeared only at an ammonia concentration of 20-30 mg/L and higher, mainly in the form of a burn around the anus and in the region of the external genitalia.
|
Time length (mins) |
LC50 (mg/L) |
1 |
5 |
Unable to obtain |
2 |
15 |
112±4.75 |
3 |
30 |
71.9±52 |
4 |
60 |
48.4±5.84 |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The visible signs of skin pathology appeared only at an ammonia concentration of 20-30 mg/L and higher, mainly in the form of a burn around the anus and in the region of the external genitalia.
- Executive summary:
The visible signs of skin pathology appeared only at an ammonia concentration of 20-30 mg/L and higher, mainly in the form of a burn around the anus and in the region of the external genitalia. The LC50 was 112±4.75 mg/L after 15 mins of exposure.
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