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EC number: 700-397-7 | CAS number: 847488-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.
Data source
Reference
- Reference Type:
- other: SNIF
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- other: no data
- Limit test:
- yes
Test material
- Reference substance name:
- A mixture of: esters of C14-C15 branched alcohols with 3,5-di-t-butyl-4-hydroxyphenyl propionic acid; C15 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate; C13 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate
- EC Number:
- 413-750-2
- EC Name:
- A mixture of: esters of C14-C15 branched alcohols with 3,5-di-t-butyl-4-hydroxyphenyl propionic acid; C15 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate; C13 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate
- IUPAC Name:
- 413-750-2
- Reference substance name:
- reaction mass of: esters of C14-C15 branched alcohols with 3,5-di-t-butyl-4-hydroxyphenyl propionic acid; C15 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate; C13 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate
- IUPAC Name:
- reaction mass of: esters of C14-C15 branched alcohols with 3,5-di-t-butyl-4-hydroxyphenyl propionic acid; C15 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate; C13 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate
- Test material form:
- not specified
- Details on test material:
- Physical form of substance: L
Mass median aerodynamic diameter (for liquid and solid aerosol): Particle size determination indicated 94.0% and 93.9% of the test aerosol particles to be <3.5µm for groups 1 and 2 respectively
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- The nominal concentrations administered were 87.85 mg/L (group 1) and 70.14mg/L (group 2).
- No. of animals per sex per dose:
- - Male: 5
- Female: 5 - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 7.5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- - Male: 4.07 mg/L; Number of animals: 5; Number of deaths: 0
- Male: 7.53 mg/L; Number of animals: 5; Number of deaths: 0
- Female: 4.07 mg/L; Number of animals: 5; Number of deaths: 0
- Female: 7.53 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: An unkempt appearance was noted for all Group 1 animals immediately post dose and one animal of Group 2 appeared subdued and showed hunched posture over the first 24h post dose. Otherwise no other abnormalities w
- Body weight:
- There was no effect on body weight profile following exposure to the test substance.
- Gross pathology:
- Necropsy examination:
All Group 1 animals were seen to have no abnormalities.
Slightly mottled lungs in all but 2 Group 2 animals and pale/discoloured lungs were noted in one Group 2 male and 1 Group 2 female. These were
deemed to be in accordance with normal background findings in acute rat studies at IRI and not attributable to treatment.
Body weight ratio:
Lung:body weight ratios were generally within normal limits for all animals, although Group 2 males tended towards the bottom of the expected
range.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Eu GHS
- Conclusions:
- LC50 (rat) > 7.5 mg/L air (4h)
The test substance did not produce any evidence of toxicity in Sprague-Dawley rats following exposure for 4 h to an atmosphere containing 7.53 mg/L air (measured gravimetrically). - Executive summary:
The acute inhalation toxicity of the structural analogue has been determined in a GLP test with rats according to OECD Guideline No. 403. The test substance did not produce any evidence of toxicity in Sprague-Dawley rats following exposure for 4 h to an atmosphere containing 7.53 mg/L air (measured gravimetrically), so the LC50 value is > 7.5 mg/L air (4h).
Since EC 700-397-7 is a near analogue to the test substance (EC 413-750-2), the experimental data from this substance were used in a read-across approach.
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