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Diss Factsheets
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EC number: 205-500-4 | CAS number: 141-78-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Original study cited not reviewed. Included for completion only using information from a secondary source. Study covers mixed solvent exposure therefore of little use for identifying effects of ethyl acetate alone unless study is completely negative.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Tuohimaa, P., Wichmann, L.
- Year:
- 1 987
- Bibliographic source:
- Chapter 5 In Hemminki, K. et al. (eds.): Occupational Hazards and Reproduction, Hemisphere Publishing Corp., Washington DC
Materials and methods
- Study type:
- other: no data
- Endpoint addressed:
- toxicity to reproduction / fertility
- Principles of method if other than guideline:
- no further information available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl acetate
- EC Number:
- 205-500-4
- EC Name:
- Ethyl acetate
- Cas Number:
- 141-78-6
- Molecular formula:
- C4H8O2
- IUPAC Name:
- ethyl acetate
Constituent 1
Method
- Type of population:
- occupational
- Details on study design:
- SETTING: printing factory workers occupationally exposed (for an undisclosed time) to an atmosphere reportedly containing ethyl acetate at 150 ppm (549 mg/m3) and other organic solvents.
STUDY POPULATION
- Total number of subjects participating in study: 11
HEALTH EFFECTS STUDIED
- Other health effects: sperm count. - Exposure assessment:
- not specified
Results and discussion
- Results:
- No effects on sperm count were detected
Applicant's summary and conclusion
- Executive summary:
No effects on sperm count were detected in a study of eleven printing factory workers occupationally exposed (for an undisclosed time) to an atmosphere reportedly containing ethyl acetate at 150 ppm (549 mg/m3) and other organic solvents. The study covered mixed solvent exposure but since the result was negative, it can be concluded that ethyl acetate causes no adverse effects in this exposure setting.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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