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EC number: 231-890-0 | CAS number: 7775-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- This study report is a revised version of a study report from 1973. Minor deviations from the guideline without an effect on the results: - The stability of the test material was missing. -According to the guideline the observation period should be at least 14 day. In this study an observation period of 7 days was used. This is considered to have no effect on the results, since none of the animals died after 24 hours. - The clinical signs were documented group-wise and there was no statement about how many animals showed signs of toxicity. According to the guideline individual records should be held and number of animals showing toxic signs should be stated. - Body weight was not determined weekly and at death, which should be done according to the guideline. -There were no details about acclimatisation period, strain, individual body weights, diet, and environmental conditions. Also, it was not stated if animals were fasted prior to substance e administration or how often clinical examinations were made.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987-02-24
- Deviations:
- yes
- Remarks:
- , "see rationale for reliability"
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium dithionite
- EC Number:
- 231-890-0
- EC Name:
- Sodium dithionite
- Cas Number:
- 7775-14-6
- Molecular formula:
- H2O4S2.2Na
- IUPAC Name:
- disodium dithionite
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Hydrosulfit konz. BASF (Sodium dithionite)
Constituent 1
- Specific details on test material used for the study:
- not specified
Test animals
- Species:
- rat
- Strain:
- other: not stated
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner rats
- Age at study initiation: young adult laboratory rats were used.
- Weight at study initiation: average weight at beginning of the test: 170 - 203 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5 % CMC-solution (cleaned sodium carboxymethylcellulose) in doubly distilled water; Suspension
- Details on oral exposure:
- The doses were administered as aqueous suspensions of 2 %, 16 %, 20 % (2000 and 2500 mg/kg) and 30 % (3200 and 6400 mg/kg) test substance in 0.5 CMC-Solution (Hoechst AG).
MAXIMUM DOSE VOLUME APPLIED: The cocnetrations of the preparations were adjusted to achieve comparable volumes (about 10 -20 ml) per kg body weight. - Doses:
- 200, 1600, 2000, 2500, 3200 and 6400 mg/kg bw
- No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy performed: yes
- Examinations performed: group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study for determination of dose. - Statistics:
- On the basis of the observed lethality, the LD50 value was estimated or determined using a graphical evaluation of the dose response curve on probability paper.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200 mg/kg bw: no deaths
1600 mg/kg bw: no deaths
2000 mg/kg bw: no deaths
2500 mg/kg bw: 3 males and 2 females died within the first 24 hours
3200 mg/kg bw: 4 males and 5 females died within the first 24 hours
6400 mg/kg bw: 5 males and 5 females died in the first hour. - Clinical signs:
- other: 6400 mg/kg bw: intermittent respiration, squatting posture and atony immediately after application. 3200 mg/kg bw: intermittent respiration, squatting posture and atony immediately after application. No clinical signs and findings in the surviving animal
- Gross pathology:
- 6400 and 3200 mg/kg bw: Congestive hyperemia, heart: dilation, stomach: dilatation, partly bloody ulcers and liquid content, intestine: hematinized, diarrheic content
2500 mg/kg bw: Congestive hyperemia, heart: dilatation, stomach: dilatation, liquid content, red discoloration of the glandular stomach, intestine: partly diffuse discoloration, diarrheic content
2000, 1600 and 200 mg/kg bw: Organs without particular findings. - Other findings:
- not stated
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 (male and female rats): approx. 2500 mg/kg bw
According to the Regulation (EC) No 1272/2008 and subsequent adaptations, the substance is not acutely toxic via the oral route.
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