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EC number: 266-946-3 | CAS number: 67701-28-4 This substance is identified by SDA Substance Name: C8-C18 and C18 unsaturated trialkyl glyceride and SDA Reporting Number: 01-001-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A lifespan study was conducted in mice to investigate the effect of feeding hydrogenated coconut oil on longevity, hepatic lipid peroxidation and hepatic fatty acid composition.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Glycerides, C8-18 and C18-unsatd.
- EC Number:
- 266-946-3
- EC Name:
- Glycerides, C8-18 and C18-unsatd.
- Cas Number:
- 67701-28-4
- Molecular formula:
- Triglycerides containing a glycerol backbone esterified to fatty acids with a carbon chain length of C8-18 as well as unsaturated C18 fatty acids
- IUPAC Name:
- Tri(C8-18 and C18-unsatd. fatty acyl)glycerol
- Details on test material:
- - Name of test material (as cited in study report): Hydrogenated coconut oil (CAS N° 84836-98-6, EC N° 284-283-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18 and C18-unsad.’
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: LAFJ and C3H1HeJ
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Jackson Laboratory, Bar Harbor, Maine
- Age at study initiation: 4 wks
- Diet (ad libitum): Purina Laboratory Chow
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DIET PREPARATION
- Rate of preparation of diet (frequency): Weekly
- Mixing appropriate amounts with (Type of food): The sucrose and hydrogenated coconut oil were blended with the powdered diet (Purina Chow) in an electric mixer.
- Storage temperature of food: Under refrigeration - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- Not applicable
- Duration of treatment / exposure:
- Entire lifespan
- Frequency of treatment:
- Daily ad libitum in diet
Doses / concentrations
- Remarks:
- Doses / Concentrations:
15% hydrogenated coconut oil
Basis:
nominal in diet
- No. of animals per sex per dose:
- 60
- Control animals:
- other: 15% sucrose in diet
- Details on study design:
- None
- Positive control:
- Not applicable
Examinations
- Observations and examinations performed and frequency:
- BODY WEIGHT: Yes
- Time schedule for examinations: At monthly intervals
LONGEVITY: Yes - Sacrifice and pathology:
- When pre-terminal (12-24 h before anticipated death), the animals were killed and portion of liver extracted to determine hepatic peroxide values and
hepatic fatty acid compositions - Other examinations:
- None
- Statistics:
- The probabilities that differences in the data were due to chance were calculated by the t test.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- No difference in longevity, body weights, hepatic peroxide values and hepatic fatty acid compositions between the groups in both the strains
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 15 other: % in diet
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: No effect on longevity, body weight, hepatic peroxide values and hepatic fatty acid compositions
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, supplementation of 15% hydrogenated coconut oil in diet did not alter lifespan, body weight and hepatic peroxide/fatty acid values of mice. The NOAEL of the study was therefore equivalent to 15% in diet.
- Executive summary:
A lifespan study was conducted in LAFJ and C3H1HeJ mice to investigate the effect of feeding hydrogenated coconut oil on longevity, hepatic lipid peroxidation and hepatic fatty acid composition.
15% hydrogenated coconut oil or sucrose was fed to 60 animals/strain/group for lifetime. Body weights were recorded at monthly intervals. When pre-terminal (12-24 h before anticipated death), the animals were killed and portion of liver extracted to determine hepatic peroxide values and
hepatic fatty acid compositions.
No differences were observed in longevity, body weights, hepatic peroxide values and hepatic fatty acid compositions between the groups in both the strains. No information was provided about the general toxicological effects.
Under the test conditions, the NOEAL was determined to be equivalent to 15% hydrogenated coconut oil in the diet.
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