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Diss Factsheets
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EC number: 201-236-9 | CAS number: 79-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Several studies have investigated TBBPA’s potential for absorption and elimination in environmentally relevant species, e.g. fish, oysters, birds, earthworms. The results are consistent with similar studies in humans and rats (see section 5.1 of the CSR) demonstrating that TBBPA is rapidly metabolized and eliminated and has little to no potential for bioaccumulation.
After exposure to TBBPA in water, fish rapidly reached steady-state tissue concentrations with measured BCFs of ca. 150. Fish also rapidly eliminated TBBPA once removed to fresh water with 50% elimination of the 14C-residues present in the tissue of fathead minnows on the last day of exposure occurring during the first 24 hours of depuration. After oral exposure of quail, TBBPA was rapidly eliminated via bile and excreted in faeces, and transfer to egg yolks was low. After egg yolk injection, TBBPA’s transfer to the growing embryo was low, and that amount transferred was readily excreted by the embryo. Thus, the risk for bioaccumulation or embryonic exposure following dietary intake in laying birds is expected to be low. TBBPA did not bioaccumulate in earthworms after prolonged exposure. Based on these studies, TBBPA has little potential to bioconcentrate or bioaccumulate. This is likely related to the organisms’ ability to metabolize TBBPA to readily eliminated forms.
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