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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-01-09 to 1985-04-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conduction and documentation of study very acceptable. Study report available.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- publication
- Title:
- The acute toxicity and primary irritancy of 2,4-pentanedione
- Author:
- Ballantyne, B., Dodd, D.E., Myers R.C., Nachreiner, D.J.
- Year:
- 1 986
- Bibliographic source:
- Drug and Chemical Toxicology, 9, 133-146
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as stated in report
- Deviations:
- no
- Principles of method if other than guideline:
- Method: 6 female New Zealand White rabbits tested; effects scored according to Draize (1944). 0.1 ml of undiluted test substance was applied to the eyes of rabbits.
Male or female New Zealand White rabbits are dosed with 0.1 ml by instilling into the lower conjunctival sac of one eye per animal. Teh eyelids are held together for one second. Six eyes are dosed per test volume.The eyes are scored by the Draize Scoring system (Values 0 - 4 for cornea opacity and area involved, chemosis; 0-3 for redness and discharge; 0-2 for Iris) at 1, 4, 24, 48, 72 h and 7 days after dosing. Flourecein (2%) staining is used to determine corneal injury before dosing and at reading after one day. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- pentane-2,4-dione
- Details on test material:
- - Name of test material (as cited in study report): 2,4-Pentanedione
- Substance type: industrial chemical
- Physical state: liquid
- Analytical purity: > 99%
- Impurities (identity and concentrations): not reported
- Lot/batch No.: 496500
- Expiration date of the lot/batch: not given
- Stability under test conditions: stable
- Storage condition of test material: not given
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Amount applied: 0.1 ml
- Duration of treatment / exposure:
- no wasing of the eys
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM: Draize System
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: all
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1 - 4 hours
- Score:
- >= 0.2 - <= 0.8
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 - 4 hours
- Score:
- >= 0.8 - <= 1.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1 - 4 hours
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Irritant / corrosive response data:
- Slight redness of the conjunctivae was observable in 5/6 animals (average score 0.8); slight chemosis in 2/6 and moderate chemosis in 1/6 animals (average score 0.7); slight discharge in 2/6 and moderate discharge in 3/6 animals (average score 1.3); slight inflammation of the iris in 2/6 animals (average score 0.3);
Results 4 h after application of the material: Slight inflammation of the iris in 1/6 animals (score 0.2); Slight redness of the conjunctivae in 4/6 animals (average score 0.7); slight chemosis in 2/6, moderate chemosis in 1/6 animals (average score 0.7); slight conjunctival discharge in 3/6 and moderate conjunctival discharge in 2/6 animals (average score 1.2)
24 hours post-instillation all eyes healed. Opacities of the cornea were not observable at any time. - Other effects:
- none reported
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification: not irritating
- Executive summary:
6 Female New Zealand White rabbits were tested in an eye irritation test according to Draize (1944). 0.1 ml of undiluted 2,4-Pentanedione is dosed by instilling into the lower conjunctival sac of one eye per animal. The eyelids are held together for one second. The eyes are scored by the Draize Scoring system (Values 0 - 4 for cornea opacity and area involved, chemosis; 0-3 for redness and discharge; 0-2 for Iris) at 1, 4, 24, 48, 72 h and 7 days after dosing. Flourecein (2%) staining is used to determine corneal injury before dosing and at reading after one day. Results 1 h after application of the material show slight redness of the conjunctivae was observable in 5/6 animals (average score 0.8); slight chemosis in 2/6 and moderate chemosis in 1/6 animals (average score 0.7); slight discharge in 2/6 and moderate discharge in 3/6 animals (average score 1.3); slight inflammation of the iris in 2/6 animals (average score 0.3). Results 4 h after application of the material show slight inflammation of the iris in 1/6 animals (score 0.2); Slight redness of the conjunctivae in 4/6 animals (average score 0.7); slight chemosis in 2/6, moderate chemosis in 1/6 animals (average score 0.7); slight conjunctival discharge in 3/6 and moderate conjunctival discharge in 2/6 animals (average score 1.2). 24 hours post-instillation all eyes healed. Opacities of the cornea were not observable at any time. The substance did produce only slight effects (iritis and minor conjunctival irritation) not relevant for classification.
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