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EC number: 256-176-6 | CAS number: 44992-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18/07/1991-20/07/1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented report of a guideline study conducted to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- The dissolved oxyegen concentration was 4% below the required minimum of 60% of the air saturation value at the beginning of the test and 8% after 24 hours and was not measured at 48 hours.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- [2-(acryloyloxy)ethyl]trimethylammonium chloride
- EC Number:
- 256-176-6
- EC Name:
- [2-(acryloyloxy)ethyl]trimethylammonium chloride
- Cas Number:
- 44992-01-0
- Molecular formula:
- C8H16NO2.Cl
- IUPAC Name:
- Trimethyl[2-(prop-2-enoyloxy)ethyl]azanium chloride
- Details on test material:
- - Name of test material: Adame-Quat (2-(acryloyloxy)-N,N,N-trimethylethanaminium chloride)
- CAS number: 44992-01-0
- Manufacturing code: B4846
- Physical state: liquid
- Colour: clear liquid
- Analytical purity: 80 % aqueous solution
- Lot/batch No.: 40034237
- Storage condition of test material: at 4°C in the dark
- pH-value: 6.56
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The resulting dilution water had total hardness of 2.619 mmol/l calcium and magnesium ions. Carbonate content was 0.760 mmol/L. Before use the dilution water was filtered through an active carbon tilter in order to eliminate chlorinated hydrocarbons. The pH-value was 7.94. All these parameters were within the pre-set ranges.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: no data
- Source: Stockhausen laboratory
- Age at study initiation: not older than 25 hours
- Method of breeding: Beakers with a nominal capacity of 2 litres, filled with 1400 ml dilution water. Between 15 and 20 adults held in each.
- Feeding during test: during holding
- Food type: Algae: Scenedesmus subspicatus
- Amount and Frequency: daily with an appropriate amount of algae which could be roughly consumed per day.
ACCLIMATION
- Acclimation period: not required
- Acclimation conditions: same as test
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No
Test conditions
- Hardness:
- 2.619 mmol/l calcium and magnesium ions
0.760 mmol/l carbonate - Test temperature:
- Day 0: 20.2°C
Day 1: 20.4°C - pH:
- day 0: 7.53
day 1: 7.62 - Dissolved oxygen:
- Day 0: 5.1 mg/L and 56 %
Day 1: 4.7 mg/L and 52 % - Nominal and measured concentrations:
- Nominal concentrations: 5; 10; 20; 40; 80; 160; 320 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 50 ml glass beakers (with approximately 30 ml test solution)
- Type: open
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration: 5
- No. of vessels per vehicle control (replicates): 5
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: the dilution water was prepared separately in a silicon sealed glass tank by mixing de-chlorinated tap water from a municipal source with demineralised water a certain amount of sulphuric acid. The resulting dilution water had total hardness of 2.619 mmol/l calcium and magnesium ions. The carbonate content was 0.760 mmol/L.
Before usage the dilution water was filtered through an active carbon filter in order to eliminate chlorinated hydrocarbons.
OTHER TEST CONDITIONS
- Photoperiod: natural light-dark cycle and additional artificial light-dark cycle of 16 to 8 hours
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : immobilization at 24 hours and 48 hours post exposure - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 40 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 120 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes (potassium dichromate)
- Toxicity range required : EC50 = 0.9 - 1.9 mg/L
- Measured toxicity: 1.45 mg/L
Any other information on results incl. tables
Nominal Concentration (mg/L) | Number of Daphnia | Immobilized Daphnia |
|||
After 24 hours | After 48 hours | ||||
Number | Cumulative Frequency (%) | Number | Cumulative frequency (%) | ||
0 | 25 | 0 | 0 | 1 | 4 |
5 | 25 | 0 | 0 | 1 | 4 |
10 | 25 | 0 | 0 | 1 | 4 |
20 | 25 | 0 | 0 | 2 | 8 |
40 | 25 | 0 | 0 | 1 | 4 |
80 | 25 | 0 | 0 | 9 | 36 |
160 | 25 | 4 | 16 | 11 | 60 |
320 | 25 | 25 | 100 | - | 100 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance, Adam-Quat MC, was considered to be only slightly toxic to Dapnia magna, with regard to the swimming ability. Nevertheless ADAMQUAT MC is not classified harmful to aquatic invertebrates. The lowest concentration which did not cause swimming inhibition was 40 mg Adam-Quat MC per litre. Therefore the EC0 is 40 mg/l. The EC 50 was calculated to be 183 mg/L after 24 hours and 116 mg/l after 48 hours according to the EPA computer programme.
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