Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-708-7 | CAS number: 98-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable results of acute toxicity testing are available for fish, invertebrates (Daphnia), algae, and microorganisms. Studies dealing with long-term toxicity are not available. In one study the acute toxicity to fish was investigated under flow-through conditions and with analytical monitoring. The study was conducted comparable to OECD guideline 203 'Fish, acute toxicity'. Acetophenone shows a low toxicity towards Pimephales promelas: 96 h LC50 and EC50=162 mg/L. Another study was conducted according to the national standard method US EPA (1975) with analytical monitoring. Based on the results, acetophenone shows a low acute toxicity towards Pimephales promelas (96 h LC50=161 -162 mg/L). A further study was conducted according to 'Standard practice for conducting acute toxicity tests with fishes, macroinvertebraten, and amphibians (ASTM, 1980) . Test substance concentration were measured daily via GC/FID, GC/ECD and/or HPLC. Based on the results, acetophenone can be regarded as substance with a low acute toxicity towards Pimephales promelas (96 h LC50=236 mg/L). A futher study was conducted comparable to US EPA (1975). The concentrations were tested under static conditions and not measured but the test vessels were covered with glass to reduce evaportation. Based on the results, acetophenone shows a low toxicity towards Pimephales promelas (96 h LC50=155 mg/L nominal). No data from guideline studies on chronic fish toxicity are available. According to Annex IX of Regulation (EC) No 1907/2006 chronic fish toxicity tests should be proposed if the chemical safety assessment indicates the need to investigate further the effects on fish. However, overall information is sufficient for risk assessment. Therefore, testing of on chronic fish toxicity is not regarded necessary. Furthermore, the substance is proven to be ready biodegradable. In the frame of determing body burden, also the 48 h LC50 of Daphnia magna exposed to acetophenone was determined. The concentration of radiolabeled acetophenone was measured using scintillation counting. The test vials were closed with screw caps. In the static test, a 48 h LC50=528 mg/L (4.4 mmol/L, nominal) was determined. No data from guideline studies on chronic invertebrate toxicity are available. According to Annex IX of Regulation (EC) No 1907/2006 tests should be proposed if the chemical safety assessment indicates the need to investigate further the effects on invertebrates. However, overall information is sufficient for risk assessment. Therefore, testing of on chronic invertebrate toxicity is not regarded necessary. Furthermore, the substance is proven to be readily biodegradable. In a toxicity study with Raphidocelis subcapitata conducted according to OECD guideline 201 (static conditions; stoppered BOD bottles; analytical monitoring of test substance concentration), the NOEC, 72 h ECb50, and 72 h-ECr50 were determined to be 24.8 mg/L, 40 mg/L (95% C.I.: 22.9-57.1 mg/L), and 86.4 mg/L (95% C.I.: 74.6-96.2 mg/L; effective), respectively. In two slightly modified guideline studies (OECD Guideline 209) acetophenone shows no inhibition of activated sludge respiration up to concentrations of 1000 mg/L (3 h IC50>1000 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.