Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-433-3 | CAS number: 2436-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 01, 1980 to March 07, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed similarly to OECD guideline 402 with minor deviations: no data about purity, source, no certificate of analysis of the test substance and no data on environmental conditions (humidity, air changes and photoperiod)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- no data on purity, source, no certificate of analysis of the test substance and no data on environmental conditions
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,7-dimethylocta-1,6-diene
- EC Number:
- 219-433-3
- EC Name:
- 3,7-dimethylocta-1,6-diene
- Cas Number:
- 2436-90-0
- Molecular formula:
- C10H18
- IUPAC Name:
- 3,7-dimethylocta-1,6-diene
- Details on test material:
- - Name of test material (as cited in study report): 79-16229, Dihydromyrcene, 0-67-4945, 79-4-16229
- Physical state: Clear liquid
- Specific gravity: 0.74
- Sample received: December 27, 1979
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Perfection Breeders Nicholas Helf
- Age at study initiation: 8 weeks
- Weight at study initiation: 2.1-2.8 kg
- Housing: Animals were housed two/cage in suspended wire mesh cages
- Diet: Fresh Purina rabbit chow; ad libitum
- Water: Ad libitum
- Acclimation period: One week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21 °C
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Abdomen
- % coverage: ca. 10% of body surface area
- Type of wrap if used: Test material was applied directly beneath gauze patches to the abraded skin, secured in position with surgical adhesive tape and then covered with impervious material.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Test sites were not washed but wiped free of excess test material
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume with unit): 14.2-18.9 cm3
- Constant volume or concentration used: No - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Four males and six females
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed daily for signs of toxicity, pharmacological effects and mortality; body weights were recorded pretest and in the survivors on Day 14
- Necropsy of survivors performed: Yes; surviving animals were killed and examined grossly
- Other examinations performed: Dermal reaction were scored at 24 hours using Draize scoring system - Statistics:
- No data
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1/10 animal died on Day 11
- Clinical signs:
- other: - Lethargy and diarrhea were major signs of toxicity noted in all animals. - Adipsia, anorexia, ptosis, yellow nasal discharge, mucus in stool or post dose vocalisation were also noted in one or two animals.
- Gross pathology:
- - Necropsy of animal which died on Day 11 revealed heavily congested lungs and moderately dilated heart
- Necropsy of the surviving animals revealed no abnormalities except slightly ulcerated or slight to moderately scaly skin - Other findings:
- - Local irritation reactions at application site: Erythema was nonexistent to slight while edema was slight-moderate on Day 1
Any other information on results incl. tables
Table 1: Individual dermal reactions
Rabbit number |
Dose volume (cc) |
Day 1 dermal reactions |
% Remaining |
|
Erythema |
Edema |
|||
1 |
18.9 |
2 |
3 |
85 |
2# |
14.9 |
2 |
2 |
50 |
3 |
15.5 |
0 |
2 |
80 |
4# |
15.5 |
0 |
3 |
85 |
5 |
14.2 |
1 |
3 |
85 |
6# |
18.9 |
1 |
3 |
80 |
7 |
15.5 |
1 |
3 |
85 |
8# |
14.9 |
0 |
3 |
80 |
9 |
14.2 |
0 |
2 |
80 |
10# |
16.2 |
0 |
2 |
75 |
#: abraded
%remaining: the amount of material remaining on the skin, gauze and occlusive binding at 24 hours after the occlusive binding was removed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 for Dimethyloctadiene is higher than 5000 mg/kg bw in rabbits and therefore it is not classified according to the criteria of the Annex VI of Directive 67/548/EEC and according to the CLP Regulation (EC) n° 1272/2008.
- Executive summary:
In an acute dermal toxicity study (limit test) performed similarly to OECD guideline 402, a group of four male and six female New Zealand White rabbits received a single dermal dose of Dimethyloctadiene (in the report the synonym Dihydromyrcene was used) at 5000 mg/kg bw at dose volume of 14.2-18.9 cm3. Dimethyloctadiene was applied to abraded/non-abraded skin in the abdomen representing 10% of the total body surface area using an occlusive patch kept in contact with the skin for 24 hours. Parameters evaluated included survival, clinical observations, body weight gain and necropsy findings in all animals after a 14 days observation period.
Only 1/10 animal died on Day 11. Major signs of toxicity noted in all animals were lethargy and diarrhea. Adipsia, anorexia, ptosis, yellow nasal discharge, mucus in stool or post dose vocalisation were also noted in one or two animals. Necropsy of animal which died on Day 11 revealed heavily congested lungs and moderately dilated heart. Necropsy of the surviving animals revealed no abnormalities except slightly ulcerated or slight to moderately scaly skin. The acute dermal LD50 was greater than 5000 mg/kg bw. Adverse dermal reactions noted on Day 1 were nonexistent to slight erythema and slight to moderate ededma.
Under the test conditions, Dimethyloctadiene is not classified according to the criteria of the Annex VI of Directive 67/548/EEC and according to the CLP Regulation (EC) n° 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.