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EC number: 234-123-8 | CAS number: 10543-57-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The test was not performed according to OECD Guideline and GLP. However, the test design reflects the basic principles of OECD Guideline 111 and is the most appropriate for this substance as it mimics its use conditions. Also, a laboratory quality control system was in place.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Perhydrolysis: 1.5 g of a persalt, 1.0 g disodium carbonate and 0.3 g sodium disilicate (3NaG) were stirred in 1 litre tap water at room temperature (approx. 20°C). To that suspension 0.54 g Peractive AC white (92 % TAED) were added. At each time interval 20 ml of the suspension were withdrawn and acidified with c = 0.5 mol/l sulphuric acid to stop the reaction. After addition of 10 ml acetonitrile/methanol (1/1) to improve the solubility of TAED and of the perhydrolysis products the volume was made up to 100 ml with tap water. The solution was filtered through a 0.2 µm membrane filter and injected into the HPLC instrument.
Hydrolysis: Same procedure as perhydrolysis but without persalt - GLP compliance:
- no
Test material
- Reference substance name:
- N,N'-ethylenebis[N-acetylacetamide]
- EC Number:
- 234-123-8
- EC Name:
- N,N'-ethylenebis[N-acetylacetamide]
- Cas Number:
- 10543-57-4
- Molecular formula:
- C10H16N2O4
- IUPAC Name:
- N,N'-ethylenebis[N-acetylacetamide]
- Details on test material:
- - Name of test material (as cited in study report): Peractive AC white
- Physical state: granule
- Composition of test material, percentage of components: TAED granule with 92% active content and carboxy methyl cellulose as granulating
auxiliary
- Lot/batch No.: DEADG5M003
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable - Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products:
Perhydrolysis: sampling after 5, 10, 20, 30, 60 and 120 minutes
Hydrolysis: sampling after 5, 10, 20, 30, 60, 120 minutes, 3 h, 4 h, 5 h, 6 h,
7 h, 8 h, 9 h and 24 h
- Sampling method:
Perhydrolysis and Hydrolysis: At the soecified time intervals 20 ml of the
suspension were withdrawn and acidified with c = 0.5 mol/l sulphuric
acid to stop the reaction. After addition of 10 ml acetonitrile/methanol (1/1)
to improve the solubility of TAED and of the perhydrolysis products the
volume was made up to 100 ml with tap water. The solution was filtered
through a 0.2 µm membrane filter and injected into the HPLC instrument.
- Sampling intervals/times for pH measurements:
Perhydrolysis: sampling after 5, 10, 20, 30, 60 and 120 minutes
Hydrolysis: sampling after 5, 10, 20, 30, 60, 120 minutes, 3 h, 4 h, 5 h, 6 h,
7 h, 8 h, 9 h and 24 h
- Other observation, if any (e.g.: precipitation, color change etc.):
Appearance of the solution before addition of Peractive AC white: Turbid,
contains undissolved particles - Buffers:
- no buffer was used, only tap water
- Estimation method (if used):
- Estimation of disappearance time (DT50) was determined by reading from the log c versus time curve of the reaction.
- Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: measuring glas flasks
TEST MEDIUM
- Kind and purity of water: tap water
- Preparation of test medium:
1.5 g sodium perborate monohydrate (perhydrolysis test only), 1.0 g disodium carbonate
and 0.3 sodium disilicate (3NaG) were stirred in 1 litre tap water at room
temperature (approx. 20°C). To that suspension were 0.54 g Peractive AC white
(92 % TAED) added.
Duration of test
- Duration:
- 24 h
- Initial conc. measured:
- ca. 499 mg/L
- Number of replicates:
- One replicate per time point for Perhydrolysis
One replicate per time point for Hydrolysis - Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- For Perhydrolysis: degradation kinetics with calculation of rate constant and half-life according to OECD 111
For Hydrolysis: Determination of DT50 by graphical analysis
Results and discussion
- Preliminary study:
- no preliminary study was performed
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- tri acetyl ethylene diamine (TriAED)
- Identifier:
- common name
- Identity:
- tri acetyl ethylene diamine (TriAED)
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- di acetyl ethylene diamine (DAED)
- Identifier:
- common name
- Identity:
- di acetyl ethylene diamine (DAED)
- Details on hydrolysis and appearance of transformation product(s):
- Perhydrolysis: The perhydrolysis of TAED can be regarded as pseudo-first order reaction. The rate constant k(obs) was 0.0038 s-1 and the half-life t(0.5) 184 s (calculated according to OECD 111 (12 May 1981).
Hydrolysis: The hydrolysis of TAED is a complex reaction. Neither pseudo-first order nor second order fitting could be applied. The rate constant was
therefore not calculated. The disappearance time DT(50) was 19 min (determined by reading from the log c versus time curve of the reaction)
(for further details see "remarks on results including tables and figures")
Total recovery of test substance (in %)
- % Recovery:
- > 88 - <= 112
- pH:
- 10
- Temp.:
- 21 °C
- Duration:
- > 0.08 - <= 24 h
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 10
- Temp.:
- 21 °C
- DT50:
- 19 min
- Type:
- other: DT50 was determined by reading from the log c versus time curve of the reaction
- Remarks on result:
- other: Hydrolysis rate constant could not be calculated, as neither pseudo-first order nor second order fitting could be applied.
- pH:
- 9
- Temp.:
- 21 °C
- DT50:
- 3.2 h
- Remarks on result:
- other: DT50 calc. from pH 10 Hydrolysis results
- pH:
- 7
- Temp.:
- 21 °C
- DT50:
- 13 d
- Remarks on result:
- other: DT50 calc. from pH 10 Hydrolysis result
- pH:
- 10
- Temp.:
- 23 °C
- Hydrolysis rate constant:
- ca. 0.23 min-1
- DT50:
- ca. 3 min
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: Values for Perhydrolysis i.e. in the presence of sodium perborate monohydrate
- Details on results:
- see "remarks on results including tables and figures
Any other information on results incl. tables
Perhydrolysis
|
TAED content |
TriAED content |
DAED content |
recovery rate |
|||
|
mg/l |
mmol/l |
mg/l |
mmol/l |
mg/l |
mmol/l |
% |
sample weight t = 5 min t = 10 min t = 20 min t = 30 min t = 60 min t = 120 min |
499 161 37 6 <1 <1 <1 |
2.19 0.70 0.16 0.02 <0.01 <0.01 <0.01 |
-- 22 8 <1 <1 <1 <1 |
-- 0.12 0.04 <0.01 <0.01 <0.01 <0.01 |
-- 185 353 368 362 365 363 |
-- 1.29 2.45 2.56 2.51 2.54 2.52 |
-- 96 121 118 115 116 115 |
TriAED = triacetyl ethylene diamine
DAED = diacetyl ethylene diamine
Hydrolysis
|
TAED content |
TriAED content |
DAED content |
recovery rate |
|||
|
mg/l |
mmol/l |
mg/l |
mmol/l |
mg/l |
mmol/l |
% |
sample weight t = 5 min t = 10 min t = 20 min t = 30 min t = 60 min t = 120 min t = 3 h t = 4 h t = 5 h t = 6 h t = 7 h t = 8 h t = 9 h t = 24 h |
499 373 343 271 211 107 37 16 8 4 3 <1 <1 <1 <1 |
2.19 2.59 2.38 1.88 1.47 0.74 0.25 0.11 0.06 0.03 0.02 <0.01 <0.01 <0.01 <0.01 |
-- 43 78 139 181 217 179 146 123 96 65 46 32 25 2 |
-- 0.23 0.42 0.75 0.97 1.17 0.96 0.78 0.66 0.51 0.35 0.25 0.17 0.13 0.01 |
-- 8 10 24 34 81 151 197 235 262 279 292 311 310 352 |
-- 0.05 0.07 0.16 0.24 0.56 1.05 1.36 1.63 1.82 1.94 2.03 2.16 2.15 2.44 |
-- 88 91 96 98 101 99 101 106 107 105 104 107 105 112 |
TriAED = triacetyl ethylene diamine
DAED = diacetyl ethylene diamine
pH and temperature
|
Perhydrolysis |
Hydrolysis |
||
|
pH |
temp. |
ph |
temp. |
t = 5 min t = 10 min t = 20 min t = 30 min t = 60 min t = 120 min t = 3 h t = 4 h t = 5 h t = 6 h t = 7 h t = 8 h t = 9 h t = 24 h |
10.2 10.1 10.0 10.0 10.0 10.0 -- -- -- -- -- -- -- -- |
23.0 23.0 23.0 22.9 22.9 22.9 -- -- -- -- -- -- -- -- |
10.6 10.6 10.5 10.4 10.3 10.2 10.1 10.1 10.1 10.0 10.0 10.0 10.0 9.7 |
20.5 20.6 20.6 20.7 20.9 21.4 21.8 22.0 22.4 22.5 22.8 23.0 23.2 19.8 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
Hydrolysis of TAED was examined at pH 10 (0.54 g Peractive AC white (92 % TAED) in 1 L tap water containing 1.0 g disodium carbonate and 0.3 sodium disilicate) at room temperature (appr. 21°C). The results show that hydrolysis does neither follow 1stnor 2ndorder kinetic. Thus, the determined first half-life of 0.3 hours will decrease over time.
Perhydrolysis was studied under the conditions similar to the washing process (at pH 10 in the presence of perborate, disodium carbonate, sodium disilicate) at room temperature (appr. 23°C). TAED hydrolyzed rapidly with a half-live of 3 minutes (1storder kinetic).
The initial hydrolysis product was triacetyl ethylenediamine which was further hydrolyzed to diacetyl ethylenediamine.
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