Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-873-5 | CAS number: 100-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Non-human data:
Data on the skin sensitization potential of phenylhydrazine was available. A 10 % solution of phenylhydrazine in alcohol was painted on a skin site that had been pretreated 2–3 weeks previously with undiluted phenylhydrazine (Jadassohn, 1930). Very intense erythema and swelling, followed by scaling and encrustation, were consistently seen.
Human data:
There are a number of case reports of skin hypersensitivity reactions to phenylhydrazine and its hydrochloride salt in humans. Solomons (1946) conducted a patch test in one subject with a phenylhydrazine crystal placed on the forearm under a dressing. Marked erythema and some oedema developed on the exposure site after 18 h, with the formation of vesicles after 30 h and crusting after a further 24 h. Similar hypersensitive skin reactions were reported following individual exposures to solid or aqueous solutions of phenylhydrazine or phenylhydrazine salts (Wright & Joyner, 1930; Frost & Hjorth, 1959; Pevny & Peter, 1983). There is also evidence that cross-sensitization can occur between hydrazine compounds, so that subjects already sensitized to hydrazine, a known skin sensitizer, are also sensitized to hydrazine derivatives, including phenylhydrazine (Malten, 1962; Van Ketel, 1964; Hovding, 1967; Rothe, 1988).
No data are available on the potential of phenylhydrazine to cause respiratory tract sensitization.
Migrated from Short description of key information:
Phenylhydrazine was considered a skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No information was available for respiratory tract sensitization.
Justification for classification or non-classification
Based on results available, phenylhydrazine was classified and labelled as skin sensitizer R, 43 according to Directive 67/548/EEC (DSD) and as skin sensitizer cat. 1 (H317) according to Regulation 1272/2008/EC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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