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EC number: 203-710-0
CAS number: 109-83-1
Leung and Blaszcak, 1998. The Skin
Sensitization Potential of Four Alkylalkanolamines. Publication.
Comparable to the OECD guideline 406.
The skin sensitization potential of
N-methylethanolamine (MMEA) was evaluated in a guinea pig maximation
procedure by the method of Magnusson and Kligman. Eighteen of the 20
animals challenged with a 5% concentration of MMEA were free of skin
response, and the 2 remaining animals had clear skin response (scores of
1) at 24 h but not at 48 h following dosing. No skin response occured in
the irritation control animals treated at the same concentration.
MMEA is considered to have sensitization
The skin sensitization potential of
N-methylethanolamine was evaluated in a guinea pig maximization
procedure by the method of Magnusson and Kligman (Leung and Blaszcak,
1998). Pretest screening allowed the selection of test concentrations
for induction and challenge phases. Intradermal injection of 5 % MMEA in
propylene glycol produced only minor local reaction, 25 % MMEA was the
highest concentration that produced only mild irritation and was used
for the epicutaneous induction. 5 % of MMEA was the highest
concentration which did not produce irritation and was used for the
epicutaneous challenge. Eighteen of the 20 animals challenged with a 5 %
concentration of MMEA were free of skin response, and the 2 remaining
animals had clear skin response (scores of 1) at 24 h but not at 48 h
following dosing. The failure to observe a response at 48 hours is
suggestive of irritation and not sensitisation in these animals.
Moreover, no skin response occurred in the irritation control animals
treated at the same concentration.
In conclusion, MMEA is considered to have a
mild potential to produce skin sensitization in guinea pigs.
to the criteria of Classification, Labelling and Packaging of Substances
and Mixtures Regulation (EC) No 1272/2008 (CLP Regulation),
classification is not warranted.
the Guinea Pig Maximisation Test, a dermal response to MMEA was observed
in 2 of 20 animals (10 %) after 24h but not 48h when challenged with 5 %
MMEA, the highest non-irritant concentration determined in a range
to tables 3.4.3 and 3.4.4 (section 126.96.36.199.3 of Annex I to CLP
Regulation), classification as skin sensitizer is only warranted when at
least 30 % of test animals show an allergic response to the test
substance in the Guinea Pig Maximisation Test.
Besides the substance is classified as:
- Acute toxicity - oral: Cat 4,
H302:harmful if swallowed
- Acute toxicity -dermal: Cat 4,
H312:harmful in contact with skin.
-Skin Corr.1B, H314:causes severe
skin burns and eye damage
- Eye Damage 1:H318:causes serious
- STOT SE Cat.3, H335:may cause
respiratory irritation, C>=5%
- Repro 2, H361 F/D: Suspected of
damaging fertility or the unborn child <state specific effect if known>
<state route of exposure if it is conclusively proven that no other
routes of exposure cause the hazard>.
- STOT RE Cat 2,H373: May cause
damage to organs <or state all organs affected, if known> through
prolonged or repeated exposure <state route of exposure if it is
conclusively proven that no other routes of exposure cause the hazard>;
Affected organs: other: the kidney, testes, epidymides, ovaries, liver,
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