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Diss Factsheets
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EC number: 213-635-5 | CAS number: 996-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- BASF-Test:
Young adult laboratory mice were purchased from breeder. Several groups of 5 mice per sex and dose are treated simultaneously with preparations of the test substance in a suitable vehicle. The substance is injected into the peritoneal cavity. The concentrations of the preparations were used to achieve comparable volumes per kg body weight. Group-wise documentation of clinical signs is performed during the study period of 7 days. - GLP compliance:
- no
Test material
- Reference substance name:
- N,N-dimethylisopropylamine
- EC Number:
- 213-635-5
- EC Name:
- N,N-dimethylisopropylamine
- Cas Number:
- 996-35-0
- Molecular formula:
- C5H13N
- IUPAC Name:
- dimethyl(propan-2-yl)amine
- Details on test material:
- - Name of test material (as cited in study report): N, N-Dimethylisopropylamin
- Purity: 99%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ivanovas
- Mean weight at study initiation: 23.9 g (females), 27.7 g (males)
no further data available
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 100, 147, 215, 316, 464 and 681 µL/kg bw (=> 72, 106, 155, 228, 334 and 490 mg/kg bw, based on a density of 0.72 g/cm³)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations and weighing: animals were observed for mortality and clinical signs 1, 24 and 48 h and 8 days after application; weighing was done at study initiation and on day 2 and 8 (surviving animals)
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 72 - < 106
- Mortality:
- - 72 mg/kg bw: 1/10 (1 animal died within 48 h)
- 106 mg/kg bw: 6/10 (1 animal died within 48 h and 5 within the first week)
- 155 mg/kg bw: 10/10 (4 animals died within 24 h, 2 within the second day and 4 within the first week after application)
- 334 and 228 mg/kg bw: 20/20 (all animals died within 24 h after application)
- 490 mg/kg bw: 10/10 (7 animals died within the first hour after application, 3 within 24 h) - Clinical signs:
- Dyspnoea, apathy, tremor, poor general state, spastical gait, abdominal position, convulsions
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.