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Diss Factsheets
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EC number: 202-992-2 | CAS number: 101-96-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Four different fish species (Bluegill Sunfish, Rainbow Trout, Fathead Minnow and Oryzias latipes) were exposed to 44PD in a static test (Oryzias latipes were exposed in a semi static test). All tests were carried out according to (then existing) guidelines and under GLP. The 96hr-LC50 values for the different species were close, the lowest 96hr LC50 value was obtained for Fathead Minnow and was 0.13 mg/L. The highest 96hr LC50 value was obtained for Rainbow trout and was 1.4 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.13 mg/L
Additional information
Short term data are available for 4 different test species form independent studies. The results of the studies are shown below:
Species |
96hr LC50 (95% conf int) |
NOEC |
Bluegill Sunfish (Lepomis macrochirus) |
0.18 (0.10 - 0.32) |
0.10 |
Rainbow Trout (Salmo gairdneri) |
0.13 (0.12 - 0.14) |
0.056 |
Fathead minnow (Pimephalus promelas) |
0.13 (0.10 - 0.18) |
0.10 |
Japanese killfish (Oryzias latipes) |
0.368 (0.108 - 0.543) |
0.108 (not a NOEC but LC0) |
The results show little variation over the different species. Also in all studies the 24 and 48hr LC50 values were measured. The 48 hr LC50 values were very close or the same as the 96 hr LC50 values (see the study summaries). From these results it can be concluded that the results are not biassed by slow uptake of the compound by the fish.
The lowest 96 hr LC50 value is for Fathead Minnow, so this is taken as the 96hr LC50 value that is representative for fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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